benzothiophene-6-carbaldehyde

Base Information

• Chemical Name: benzothiophene-6-carbaldehyde
• CAS No.: 6386-80-7
• Molecular Formula: C₉H₆OS
• Molecular Weight: 162.212
• Hs Code.: 2934999090
• Mol file: 6386-80-7.mol

Synonyms:1-Benzothiophene-6-carboxaldehyde;6-Formylbenzo[b]thiophene

Chemical Property of benzothiophene-6-carbaldehyde

Chemical Property:

• Vapor Pressure: 0.000944mmHg at 25°C
• Melting Point: 42.0-42.5 °C
• Boiling Point: 303.2°C at 760 mmHg
• Flash Point: 137.2°C
• PSA: 45.31000
• Density: 1.3g/cm³
• LogP: 2.71380
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

Benzo[b]thiophene-6-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzothiophene-6-carbaldehyde

There total 11 articles about benzothiophene-6-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

6-bromobenzothiophene (17347-32-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → benzo[b]thiophene-6-carbaldehyde (6386-80-7)

Guidance literature:

6-bromobenzothiophene; With magnesium; In tetrahydrofuran; for 2h; Reflux;

N,N-dimethyl-formamide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 70.0%

4,5-dihydrobenzo[b]thiophene-6-carbaldehyde (202350-59-2) → benzo[b]thiophene-6-carbaldehyde (6386-80-7)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; Heating;

Reference yield:

6-methylbenzo[b]thiophene (16587-47-6) + 4-methylbenzo[b]thiophene (14315-11-8) + dibenzoyl peroxide (94-36-0) → benzo[b]thiophene-6-carbaldehyde (6386-80-7) + benzo[b]thiophene-4-carboxaldehyde (10133-25-2)

Guidance literature:

With N-Bromosuccinimide; hexamethylenetetramine; In water; acetic acid; benzene; for 2h; Heating / reflux;

upstream raw materials:

4,5-dihydrobenzo[b]thiophene-6-carbaldehyde

6-methylbenzo[b]thiophene

4-methylbenzo[b]thiophene

dibenzoyl peroxide

Downstream raw materials:

benzo[b]thiophene-6-carboxylic acid