6-(4-Methoxycinnamoyl)-2-(4-methoxyphenyl)chromone

Base Information

• Chemical Name: 6-(4-Methoxycinnamoyl)-2-(4-methoxyphenyl)chromone
• CAS No.: 154185-52-1
• Molecular Formula: C₂₆H₂₀O₅
• Molecular Weight: 412.442
• Wikidata: Q76310982
• Mol file: 154185-52-1.mol

Synonyms:6-(4-Methoxycinnamoyl)-2-(4-methoxyphenyl)chromone;2-(4-Methoxyphenyl)-6-(3-(4-methoxyphenyl)-1-oxo-2-propenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2-(4-methoxyphenyl)-6-(3-(4-methoxyphenyl)-1-oxo-2-propenyl)-;154185-52-1;C26H20O5;C26-H20-O5

Chemical Property of 6-(4-Methoxycinnamoyl)-2-(4-methoxyphenyl)chromone

Chemical Property:

• Vapor Pressure: 5.49E-16mmHg at 25°C
• Boiling Point: 634.2°Cat760mmHg
• Flash Point: 274.6°C
• Density: 1.258g/cm³
• XLogP3: 5.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 412.13107373
• Heavy Atom Count: 31
• Complexity: 695

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C=CC(=O)C2=CC3=C(C=C2)OC(=CC3=O)C4=CC=C(C=C4)OC
• Isomeric SMILES: COC1=CC=C(C=C1)/C=C/C(=O)C2=CC3=C(C=C2)OC(=CC3=O)C4=CC=C(C=C4)OC

Technology Process of 6-(4-Methoxycinnamoyl)-2-(4-methoxyphenyl)chromone

There total 3 articles about 6-(4-Methoxycinnamoyl)-2-(4-methoxyphenyl)chromone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,4-bis(4-methoxycinnamoyl)phenol (106549-35-3) → 2-(4-Methoxy-phenyl)-6-[(E)-3-(4-methoxy-phenyl)-acryloyl]-chromen-4-one (154185-52-1)

Guidance literature:

With iodine; In dimethyl sulfoxide; for 0.25h;

Reference yield:

2,4-diacetylphenol (30186-16-4) → 2-(4-Methoxy-phenyl)-6-[(E)-3-(4-methoxy-phenyl)-acryloyl]-chromen-4-one (154185-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / KOH / methanol

2: 88 percent / iodine / dimethylsulfoxide / 0.25 h

With potassium hydroxide; iodine; In methanol; dimethyl sulfoxide;

Reference yield:

o-hydroxyacetophenone (118-93-4,104809-67-8) → 2-(4-Methoxy-phenyl)-6-[(E)-3-(4-methoxy-phenyl)-acryloyl]-chromen-4-one (154185-52-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / AlCl₃ / CS₂ / 1 h / Heating

2: 89 percent / KOH / methanol

3: 88 percent / iodine / dimethylsulfoxide / 0.25 h

With potassium hydroxide; aluminium trichloride; iodine; In methanol; carbon disulfide; dimethyl sulfoxide;

upstream raw materials:

2,4-bis(4-methoxycinnamoyl)phenol

2,4-diacetylphenol

o-hydroxyacetophenone

Refernces