Ethyl 2-amino-3-hydroxypropanoate hydrochloride

Base Information

• Chemical Name: Ethyl 2-amino-3-hydroxypropanoate hydrochloride
• CAS No.: 3940-27-0
• Molecular Formula: C5H11 N O3 . Cl H
• Molecular Weight: 133.1457
• Hs Code.: 2922509090
• European Community (EC) Number: 247-624-1,609-670-4
• NSC Number: 29417
• DSSTox Substance ID: DTXSID10381756
• Mol file: 3940-27-0.mol

Synonyms:3940-27-0;ethyl 2-amino-3-hydroxypropanoate hydrochloride;H-DL-Ser-OEt.HCl;DL-Serine ethyl ester hydrochloride;H-DL-Serine ethyl ester HCl;Ethyl L-serinate hydrochloride;D,L-serine ethyl ester hydrochloride;MFCD00067544;DL-Serine Ethyl Ester Hydrochoride;NSC 29417;H-Ser-OEt .HCl;Ethyl L-serinate HCl;EINECS 247-624-1;MFCD00012594;MFCD00191020;DL-SERINE ETHYL ESTER HCL;SCHEMBL1553115;DTXSID10381756;JZJQCLZQSHLSFB-UHFFFAOYSA-N;NSC29417;FD3050;NSC-29417;Serine,ethyl ester,hydrochloride(9ci);AKOS009157721;DS-16248;SY016021;SY030352;SY035107;CS-0022343;FT-0625916;FT-0628013;FT-0689474;EN300-50269;ethyl 2-amino-3-hydroxypropanoate;hydrochloride;ETHYL2-AMINO-3-HYDROXYPROPANOATEHYDROCHLORIDE;(R)-2-Tetrahydroisoquinoline acetic acidhydrochloride

Chemical Property of Ethyl 2-amino-3-hydroxypropanoate hydrochloride

Chemical Property:

• Vapor Pressure: 0.00407mmHg at 25°C
• Melting Point: 98oC
• Boiling Point: 247.9°Cat760mmHg
• Flash Point: 103.7°C
• PSA: 72.55000
• Density: 1.146g/cm³
• LogP: 0.37140
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 169.0505709
• Heavy Atom Count: 10
• Complexity: 94.2

Purity/Quality:

97% ^*data from raw suppliers

H-DL-Serine ethyl ester HCl ^*data from reagent suppliers

Safty Information:

• Statements: 22-36/37/38
• Safety Statements: 22-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(CO)N.Cl
• Uses: H-DL-Serine ethyl ester HCl

Technology Process of Ethyl 2-amino-3-hydroxypropanoate hydrochloride

There total 5 articles about Ethyl 2-amino-3-hydroxypropanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethanol (64-17-5) + N-Boc-DL-serine (3850-40-6) → serine ethyl ester hydrochloride (3940-27-0,104055-46-1)

Guidance literature:

With thionyl chloride;

DOI:10.1039/d1cc01285a

Reference yield: 95.0%

→ serine ethyl ester hydrochloride (3940-27-0,104055-46-1)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃;

Reference yield: 93.4%

ethanol (64-17-5) + L-serin (56-45-1,83245-15-2) → serine ethyl ester hydrochloride (3940-27-0,104055-46-1)

Guidance literature:

With thionyl chloride; for 11h; Cooling with ice; Reflux;

upstream raw materials:

ethanol

serin

L-serin

N-Boc-DL-serine

Downstream raw materials:

N-(N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl)-Ξ-serine ethyl ester

benzyloxycarbonylserine ethyl ester

4-carboethoxy-2-phenyl-2-oxazoline

2-[bis-(2-chloro-ethyl)-amino]-2-oxo-2λ⁵-[1,3,2]oxazaphospholidine-4-carboxylic acid ethyl ester