3,5-Dihydro-5-phenyl-3-(phenylmethyl)-4H-imidazo(4,5-c)(1,8)naphthyridin-4-one

Base Information

Chemical Name:3,5-Dihydro-5-phenyl-3-(phenylmethyl)-4H-imidazo(4,5-c)(1,8)naphthyridin-4-one
CAS No.:139339-11-0
Molecular Formula:C₂₂H₁₆N₄O
Molecular Weight:352.395
Hs Code.:
DSSTox Substance ID:DTXSID60161020
Nikkaji Number:J454.450A
Wikidata:Q83029379
Pharos Ligand ID:FGZW386J753L
ChEMBL ID:CHEMBL318502
Mol file:139339-11-0.mol

Synonyms:KF18280;KF 18280;CHEMBL318502;3,5-Dihydro-5-phenyl-3-(phenylmethyl)-4H-imidazo(4,5-c)(1,8)naphthyridin-4-one;4H-Imidazo(4,5-c)(1,8)naphthyridin-4-one, 3,5-dihydro-5-phenyl-3-(phenylmethyl)-;139339-11-0;SCHEMBL7272788;DTXSID60161020;BDBM50092623;KF-18280;LS-80030;3-Benzyl-5-phenyl-3,5-dihydro-1,3,5,6-tetraaza-cyclopenta[a]naphthalen-4-one;3-Benzyl-5-phenyl-3,5-dihydro-1,3,5,6-tetraaza-cyclopenta[a]naphthalen-4-one(KF 18280)

Suppliers and Price of 3,5-Dihydro-5-phenyl-3-(phenylmethyl)-4H-imidazo(4,5-c)(1,8)naphthyridin-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-Dihydro-5-phenyl-3-(phenylmethyl)-4H-imidazo(4,5-c)(1,8)naphthyridin-4-one

Chemical Property:

Vapor Pressure:3.88E-16mmHg at 25°C
Boiling Point:637.2°Cat760mmHg
Flash Point:339.2°C
Density:1.29g/cm³
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:352.13241115
Heavy Atom Count:27
Complexity:528

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)CN2C=NC3=C2C(=O)N(C4=C3C=CC=N4)C5=CC=CC=C5

Technology Process of 3,5-Dihydro-5-phenyl-3-(phenylmethyl)-4H-imidazo(4,5-c)(1,8)naphthyridin-4-one

There total 7 articles about 3,5-Dihydro-5-phenyl-3-(phenylmethyl)-4H-imidazo(4,5-c)(1,8)naphthyridin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 139339-02-9
5-phenyl-1H-imidazo<4,5-c><1,8>naphthyridin-4(5H)-one

: 139339-11-0
3-benzyl-5-phenyl-3H-imidazo[4,5-c][1,8]naphthyridin-4(5H)-one

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 2.) DMF, RT, 12 h;
DOI:10.1021/jm00093a020

Reference yield:

: 138305-19-8
1-phenyl-2H-pyrido<2,3-d><1,3>oxazine-2,4(1H)-dione

: 139339-11-0
3-benzyl-5-phenyl-3H-imidazo[4,5-c][1,8]naphthyridin-4(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) 60percent NaH / 1.) DMA, 0 deg C, 2.) DMA, 100 deg C,30 min

2: 49 percent / POCl₃ / 1 h / Heating

3: 86 percent / 28percent aq. NH₃ / tetrahydrofuran / Ambient temperature

4: sodium hydrosulfite / ethanol; H₂O / 0.17 h / 80 °C

5: 1 h / Heating

6: 1.) 60percent NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 5 h

With ammonium hydroxide; sodium disulfite; sodium hydride; trichlorophosphate; In tetrahydrofuran; ethanol; water;

Reference yield:

: 139339-01-8
4-amino-3-nitro-1-phenyl-1,8-naphthyridin-2(1H)-one

: 139339-11-0
3-benzyl-5-phenyl-3H-imidazo[4,5-c][1,8]naphthyridin-4(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrosulfite / ethanol; H₂O / 0.17 h / 80 °C

2: 1 h / Heating

3: 1.) 60percent NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 5 h

With sodium disulfite; sodium hydride; In ethanol; water;