3'-Guanylic acid,5'-O-[bis(4-methoxyphenyl)phenylmethyl]-P-(4-chlorophenyl)thymidylyl-(3'®5')-2'-deoxy-N-(2-methyl-1-oxopropyl)-,4-chlorophenyl 2-cyanoethyl ester (9CI)

Base Information

• Chemical Name: 3'-Guanylic acid,5'-O-[bis(4-methoxyphenyl)phenylmethyl]-P-(4-chlorophenyl)thymidylyl-(3'®5')-2'-deoxy-N-(2-methyl-1-oxopropyl)-,4-chlorophenyl 2-cyanoethyl ester (9CI)
• CAS No.: 73591-24-9
• Molecular Formula: C60H60 Cl2 N8 O17 P2
• Molecular Weight: 1298.03

Synonyms:

Chemical Property of 3'-Guanylic acid,5'-O-[bis(4-methoxyphenyl)phenylmethyl]-P-(4-chlorophenyl)thymidylyl-(3'®5')-2'-deoxy-N-(2-methyl-1-oxopropyl)-,4-chlorophenyl 2-cyanoethyl ester (9CI)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-Guanylic acid,5'-O-[bis(4-methoxyphenyl)phenylmethyl]-P-(4-chlorophenyl)thymidylyl-(3'®5')-2'-deoxy-N-(2-methyl-1-oxopropyl)-,4-chlorophenyl 2-cyanoethyl ester (9CI)

There total 8 articles about 3'-Guanylic acid,5'-O-[bis(4-methoxyphenyl)phenylmethyl]-P-(4-chlorophenyl)thymidylyl-(3'®5')-2'-deoxy-N-(2-methyl-1-oxopropyl)-,4-chlorophenyl 2-cyanoethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → 5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(4-chlorophenyl)thymidylyl-(3'->5')-2'-deoxy-N-(2-methyl-1-oxopropyl)-3'-guanylic acid, 4-chlorophenyl 2-cyanoethyl ester (73591-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triazole, triethylamine / dioxane; pyridine / 1.) 0 deg C, 1 h; 2.) room temp., 1 h

2: mesitylenesulfonyl 4-nitroimidazolide / N-methylimidazole / pyridine / 3 h / Ambient temperature

With 1,2,3-triazole; mesitylenesulfonyl 4-nitro-imidazolide; triethylamine; 1-methyl-1H-imidazole; In 1,4-dioxane; pyridine;

DOI:10.1248/cpb.30.3951

Reference yield:

4-chlorophenylphosphorodichloridate (772-79-2) → 5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(4-chlorophenyl)thymidylyl-(3'->5')-2'-deoxy-N-(2-methyl-1-oxopropyl)-3'-guanylic acid, 4-chlorophenyl 2-cyanoethyl ester (73591-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triazole, triethylamine / dioxane; pyridine / 1.) 0 deg C, 1 h; 2.) room temp., 1 h

2: mesitylenesulfonyl 4-nitroimidazolide / N-methylimidazole / pyridine / 3 h / Ambient temperature

With 1,2,3-triazole; mesitylenesulfonyl 4-nitro-imidazolide; triethylamine; 1-methyl-1H-imidazole; In 1,4-dioxane; pyridine;

DOI:10.1248/cpb.30.3951

Reference yield:

4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphate (65062-60-4) + N2-isobutyryl-2'-deoxy-[3']guanylic acid 4-chloro-phenyl ester 2-cyano-ethyl ester (71002-59-0) → 5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(4-chlorophenyl)thymidylyl-(3'->5')-2'-deoxy-N-(2-methyl-1-oxopropyl)-3'-guanylic acid, 4-chlorophenyl 2-cyanoethyl ester (73591-24-9)

Guidance literature:

With mesitylenesulfonyl 4-nitro-imidazolide; 1-methyl-1H-imidazole; In pyridine; for 3h; Ambient temperature;

DOI:10.1248/cpb.30.3951

upstream raw materials:

4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphate

N²-isobutyryl-2'-deoxy-[3']guanylic acid 4-chloro-phenyl ester 2-cyano-ethyl ester

C₃₇H₃₅ClN₂O₁₀P^(1-)

5'-O-(4-4'-dimethoxytrityl)thymidine

Downstream raw materials:

C₃₉H₄₂Cl₂N₈O₁₅P₂

C₅₇H₅₇Cl₂N₇O₁₇P₂

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