2,4-Dimethoxy-5-methylbenzaldehyde

Base Information

• Chemical Name: 2,4-Dimethoxy-5-methylbenzaldehyde
• CAS No.: 7149-91-9
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• NSC Number: 72348
• DSSTox Substance ID: DTXSID90291006
• Wikidata: Q82028834
• Mol file: 7149-91-9.mol

Synonyms:2,4-dimethoxy-5-methylbenzaldehyde;7149-91-9;2,4-dimethoxy-5-methyl-benzaldehyde;NSC 72348;Benzaldehyde, 2,4-dimethoxy-5-methyl-;NSC72348;SCHEMBL1534470;DTXSID90291006;NSC-72348;AM20041069;CS-0376973;FT-0710755;E87931;EN300-323274;Z1255465085

Chemical Property of 2,4-Dimethoxy-5-methylbenzaldehyde

Chemical Property:

• Vapor Pressure: 0.000683mmHg at 25°C
• Melting Point: 119-121 °C
• Refractive Index: 1.531
• Boiling Point: 308.4 °C at 760 mmHg
• Flash Point: 131.2 °C
• PSA: 35.53000
• Density: 1.089 g/cm³
• LogP: 1.82470
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 180.078644241
• Heavy Atom Count: 13
• Complexity: 170

Purity/Quality:

99%, ^*data from raw suppliers

2,4-Dimethoxy-5-methylbenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1OC)OC)C=O

Technology Process of 2,4-Dimethoxy-5-methylbenzaldehyde

There total 7 articles about 2,4-Dimethoxy-5-methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2,4-dimethoxytoluene (38064-90-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,4-dimethoxy-5-methyl-benzaldehyde (7149-91-9)

Guidance literature:

at 0 ℃; for 6h; Inert atmosphere;

DOI:10.1021/ja3057612

Reference yield:

2,4-dimethoxytoluene (38064-90-3) + N-methyl-N-phenylformamide (93-61-8) → 2,4-dimethoxy-5-methyl-benzaldehyde (7149-91-9)

Guidance literature:

With trichlorophosphate;

DOI:10.1021/ja01585a020

Reference yield:

→ 2,4-dimethoxy-5-methyl-benzaldehyde (7149-91-9)

Guidance literature:

With hydrogenchloride; aluminium trichloride; benzene; beim Erwaermen des Reaktionsgemisches mit 2,4-Dimethoxy-toluol und mit wss. HCl;

DOI:10.1021/ja01585a020

upstream raw materials:

hydrogen cyanide

2,4-dimethoxytoluene

N,N-dimethyl-formamide

N-methyl-N-phenylformamide

Downstream raw materials:

2-(2,4-Dimethoxy-5-methyl-phenyl)-5-oxo-tetrahydro-furan-3-carboxylic acid

2,4-dimethoxy-5-methylphenylmethanol

5-methyl-2,4-dimethoxy-benzoic acid

C₅₁H₈₃NO₁₂Si₂

Refernces

• 1、 -. "BENZOFURAN AND BENZOTHIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES". Page/Page column 27. . Retrieved 2009/02/11.