2-Hydroxy-4-methoxy-5-methylbenzaldehyde

Base Information

• Chemical Name: 2-Hydroxy-4-methoxy-5-methylbenzaldehyde
• CAS No.: 84422-52-6
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• European Community (EC) Number: 844-566-4
• Mol file: 84422-52-6.mol

Synonyms:2-Hydroxy-4-methoxy-5-methylbenzaldehyde;84422-52-6;Benzaldehyde, 2-hydroxy-4-methoxy-5-methyl-;SCHEMBL3639878;JIJCMVYESVILGN-UHFFFAOYSA-N;2-Hydroxy-4-methoxy-5-methyl-benzaldehyde;G75610;EN300-7461527;Z1222424474

Chemical Property of 2-Hydroxy-4-methoxy-5-methylbenzaldehyde

Chemical Property:

• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 166.062994177
• Heavy Atom Count: 12
• Complexity: 158

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1OC)O)C=O

Technology Process of 2-Hydroxy-4-methoxy-5-methylbenzaldehyde

There total 6 articles about 2-Hydroxy-4-methoxy-5-methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.86%

2,4-dihydroxy-5-methylbenzaldehyde (39828-37-0) + dimethyl sulfate (77-78-1) → 2-hydroxy-4-methoxy-5-methylbenzaldehyde (84422-52-6)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 12h; regioselective reaction;

DOI:10.1016/j.tet.2016.02.057

Reference yield: 51.0%

2,4-dimethoxy-5-methyl-benzaldehyde (7149-91-9) → 2-hydroxy-4-methoxy-5-methylbenzaldehyde (84422-52-6)

Guidance literature:

With aluminium trichloride; In dichloromethane; for 1h; Ambient temperature;

Reference yield: 29.0%

3-methyl-4-anisaldehyde (32723-67-4) → 2-hydroxy-4-methoxy-5-methylbenzaldehyde (84422-52-6)

Guidance literature:

With 2-amino-4-trifluoromethylbenzoic acid; palladium diacetate; toluene-4-sulfonic acid; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; acetic acid; at 90 ℃; for 24h; Sealed tube;

DOI:10.1021/acs.orglett.7b02906

upstream raw materials:

2,4-dihydroxy-5-methylbenzaldehyde

methyl iodide

2,4-dimethoxy-5-methyl-benzaldehyde

4-methyl resorcinol

Downstream raw materials:

2-(1-hydroxy-2-methyl-propyl)-5-methoxy-4-methyl-phenol

2-[1-(2-Hydroxy-4-methoxy-5-methyl-phenyl)-meth-(E)-ylidene]-pent-4-enoic acid ethyl ester