4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino}benzoic acid

Base Information

Chemical Name:4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino}benzoic acid
CAS No.:101248-32-2
Molecular Formula:C19H16 N4 O3
Molecular Weight:348.3553
Hs Code.:
Mol file:101248-32-2.mol

Synonyms:Benzoicacid, 4-[[(2-amino-1,4-dihydro-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-(9CI); ICI-M 247496

Suppliers and Price of 4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino}benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino}benzoic acid

Chemical Property:

Vapor Pressure:6.88E-18mmHg at 25°C
Boiling Point:652°C at 760 mmHg
Flash Point:348.1°C
Density:1.33g/cm³

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino}benzoic acid

There total 10 articles about 4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 101248-37-7
ethyl 4-prop-2-ynylamino>benzoate

: 101248-32-2
N¹⁰-propargyl-5,8-dideazapteroic acid

Guidance literature:: With sodium hydroxide; In dimethyl sulfoxide; at 25 ℃; for 24h;
DOI:10.1021/jm00156a033

Reference yield:

: 101248-36-6
ethyl 4-(prop-2-ynylamino)benzoate

: 101248-32-2
N¹⁰-propargyl-5,8-dideazapteroic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / CaCO₃ / various solvent(s) / 65 h / 25 °C

2: 30 percent / 1N NaOH / dimethylsulfoxide / 24 h / 25 °C

With sodium hydroxide; calcium carbonate; In dimethyl sulfoxide;
DOI:10.1021/jm00156a033

Reference yield:

: 77766-62-2
2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide

: 101248-32-2
N¹⁰-propargyl-5,8-dideazapteroic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / CaCO₃ / various solvent(s) / 65 h / 25 °C

2: 30 percent / 1N NaOH / dimethylsulfoxide / 24 h / 25 °C

With sodium hydroxide; calcium carbonate; In dimethyl sulfoxide;
DOI:10.1021/jm00156a033