2-AMINO-6-METHYL-4(3H)-QUINAZOLONE

Base Information

• Chemical Name: 2-AMINO-6-METHYL-4(3H)-QUINAZOLONE
• CAS No.: 50440-82-9
• Molecular Formula: C9H9N3O
• Molecular Weight: 175.19
• Hs Code.: 2933990090
• Mol file: 50440-82-9.mol

Synonyms:2-Amino-6-methyl-3-hydroquinazolin-4-one;2-Amino-6-methylquinazolin-4(3H)-one;

Chemical Property of 2-AMINO-6-METHYL-4(3H)-QUINAZOLONE

Chemical Property:

• Vapor Pressure: 3.54E-06mmHg at 25°C
• Melting Point: >300 °C
• Refractive Index: 1.701
• Boiling Point: 386.5 °C at 760 mmHg
• Flash Point: 187.5 °C
• PSA: 71.77000
• Density: 1.42 g/cm³
• LogP: 1.39490
• Storage Temp.: 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-6-methylquinazolin-4(3H)-one 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is employed as a intermediate for pharmaceutical.

Technology Process of 2-AMINO-6-METHYL-4(3H)-QUINAZOLONE

There total 8 articles about 2-AMINO-6-METHYL-4(3H)-QUINAZOLONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Amino-5-methylbenzoic acid (2941-78-8) + CYANAMID (420-04-2) → 2-amino-3,4-dihydro-6-methyl-4-oxoquinazoline (50440-82-9)

Guidance literature:

In water; at 95 ℃; for 8h; Reflux;

Reference yield: 99.0%

ethyl 2-amino-5-methylbenzoate (58677-05-7) + chloroformamidine hydrochloride (29671-92-9) → 2-amino-3,4-dihydro-6-methyl-4-oxoquinazoline (50440-82-9)

Guidance literature:

With dimethylsulfone; at 150 ℃; for 1h;

DOI:10.1021/jm00169a040

Reference yield: 87.0%

2-amino-5-methylbenzoic acid methyl ester (18595-16-9) + chloroformamidine hydrochloride (29671-92-9) → 2-amino-3,4-dihydro-6-methyl-4-oxoquinazoline (50440-82-9)

Guidance literature:

In diethylene glycol dimethyl ether; for 0.191667h; 225 deg C -> 185 deg C;

DOI:10.1002/jhet.5570260548

upstream raw materials:

2-amino-5-methylbenzoic acid methyl ester

chloroformamidine hydrochloride

ethyl 2-amino-5-methylbenzoate

2-Amino-5-methylbenzoic acid

Downstream raw materials:

2-amino-6-(bromomethyl)-4-hydroxyquinazoline

N¹⁰-propargyl-5,8-dideazapteroic acid

diethyl N-<4-methyl>prop-2-ynylamino>benzoyl>-L-glutamate

diethyl N-<4-methyl>prop-2-ynylamino>benzoyl>-L-glutamate

Refernces

• 1、 ?kerbladh, Linda,Odell, Luke R.. "Synthesis of 2-Aminoquinazolinones via Carbonylative Coupling of ortho-Iodoanilines and Cyanamide". . p. 2966 - 2973. Retrieved 2016/04/26.
• 2、 -. "QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES". Page/Page column 12; 13. . Retrieved 2012/12/13.