N-(trifluoroacetyl)leucine

Base Information

Chemical Name:N-(trifluoroacetyl)leucine
CAS No.:1480-30-4
Molecular Formula:C8H12 F3 N O3
Molecular Weight:227.183
Hs Code.:

Synonyms:L-Leucine,N-(trifluoroacetyl)- (9CI); Leucine, N-(trifluoroacetyl)- (6CI); Leucine,N-(trifluoroacetyl)-, L- (8CI); N-(Trifluoroacetyl)-L-leucine; NSC 146775

Suppliers and Price of N-(trifluoroacetyl)leucine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of N-(trifluoroacetyl)leucine

Chemical Property:

Vapor Pressure:9.4E-05mmHg at 25°C
Boiling Point:315.4°Cat760mmHg
Flash Point:144.6°C
Density:1.274g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(trifluoroacetyl)leucine

There total 10 articles about N-(trifluoroacetyl)leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 383-63-1
ethyl trifluoroacetate,

: 1480-30-4
(S)-2-(2,2,2-trifluoroacetamido)-4-methylpentanoic acid

Guidance literature:: With triethylamine; In methanol; at 20 ℃; for 15h;
DOI:10.1021/ol402341u

Reference yield:

: 1188-21-2
N-Ac-Leu

: 76-05-1
trifluoroacetic acid

: 99-15-0
N-acetylleucine

: 1480-30-4
(S)-2-(2,2,2-trifluoroacetamido)-4-methylpentanoic acid

Guidance literature:: DOI:10.1021/jo01094a627

Reference yield:

: 2743-60-4,75023-21-1
L-Leucine ethyl ester

: 1480-30-4
(S)-2-(2,2,2-trifluoroacetamido)-4-methylpentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / H₂O / 1.5 h / Heating

2: 1.) acetyl chloride / 1.) 100 degC, 40 min; 2.) CH₂Cl₂, reflux, 10 min

With hydrogenchloride; acetyl chloride; In water;
DOI:10.1016/S0040-4020(01)86059-2