1-(2,2-difluoroethyl)-4-fluorobenzene

Base Information

• Chemical Name: 1-(2,2-difluoroethyl)-4-fluorobenzene
• CAS No.: 50561-95-0
• Molecular Formula: C8H7F3
• Molecular Weight: 160.1364
• Mol file: 50561-95-0.mol

Synonyms:

Chemical Property of 1-(2,2-difluoroethyl)-4-fluorobenzene

Chemical Property:

• Vapor Pressure: 3.87mmHg at 25°C
• Boiling Point: 155.6°Cat760mmHg
• Flash Point: 40.5°C
• Density: 1.162g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,2-difluoroethyl)-4-fluorobenzene

There total 4 articles about 1-(2,2-difluoroethyl)-4-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

para-fluorostyrene (405-99-2) → 1-(2,2-difluoroethyl)-4-fluorobenzene (50561-95-0)

Guidance literature:

With 1,1,1,3',3',3'-hexafluoro-propanol; 4-tolyl iodide; In dichloromethane; for 12h; Sealed tube; Electrolysis;

DOI:10.1002/anie.201912119

Reference yield:

Toluene-4-sulfonic acid 2,2-difluoro-1-(4-fluoro-phenyl)-ethyl ester (50562-14-6) → 1-(2,2-difluoroethyl)-4-fluorobenzene (50561-95-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;

DOI:10.1021/jo00921a004

Reference yield:

2,2-difluoro-1-(4-fluorophenyl)ethan-1-one (50562-06-6) → 1-(2,2-difluoroethyl)-4-fluorobenzene (50561-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄ / dioxane; H₂O

3: H₂ / Pd-C / ethanol / Ambient temperature

With sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethanol; water;

DOI:10.1021/jo00921a004

upstream raw materials:

Toluene-4-sulfonic acid 2,2-difluoro-1-(4-fluoro-phenyl)-ethyl ester

2,2-difluoro-1-(4-fluorophenyl)ethanol

2,2-difluoro-1-(4-fluorophenyl)ethan-1-one

para-fluorostyrene

Downstream raw materials:

p-Fluoro-β-fluorostyrene