3-NITROPYRIDINE

Base Information

• Chemical Name: 3-NITROPYRIDINE
• CAS No.: 2530-26-9
• Molecular Formula: C5H4N2O2
• Molecular Weight: 124.099
• Hs Code.: 29333999
• Mol file: 2530-26-9.mol

Synonyms:3-Nitropyridine;

Chemical Property of 3-NITROPYRIDINE

Chemical Property:

• Appearance/Colour: white to yellow needle-like crystals
• Vapor Pressure: 0.2mmHg at 25°C
• Melting Point: 35-40 °C
• Refractive Index: 1.567
• Boiling Point: 217 °C at 760 mmHg
• PKA: pK1:0.79(+1) (25°C,μ=0.02)
• Flash Point: 85 °C
• PSA: 58.71000
• Density: 1.313 g/cm³
• LogP: 1.51300
• Storage Temp.: Flammables area
• Solubility.: soluble in Methanol

Purity/Quality:

99.0% ^*data from raw suppliers

3-Nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn; F
• Hazard Codes: Xn-F,Xn,F
• Statements: 20/21/22-11-41-37/38-22
• Safety Statements: 37/39-26-16-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Nitropyridine is used in the novel synthesis of biologically active nitro heterocyclic compounds.

Technology Process of 3-NITROPYRIDINE

There total 5 articles about 3-NITROPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-Hydrazino-3-nitropyridine (15367-16-5) → 3-nitropyridine (2530-26-9)

Guidance literature:

With water; oxygen; copper(II) sulfate; at 80 ℃; for 6h; Green chemistry;

DOI:10.1039/c3gc41658e

Reference yield: 80.0%

5-bromo-2-chloro-3-nitropyridine (67443-38-3) → 3-nitropyridine (2530-26-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In methanol; at 20 ℃; for 2h; under 760.051 Torr; chemoselective reaction; Sealed tube;

DOI:10.1016/j.tetlet.2014.08.008

Reference yield: 41.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 2-chloro-3-aminopyridine (6298-19-7) + 3-nitropyridine (2530-26-9)

Guidance literature:

With Me₂SiI; In chloroform; at 20 ℃; for 2h;

DOI:10.1021/jo001644s

upstream raw materials:

pyridine

sulfuric acid

2-Chloro-3-nitropyridine

2-Hydrazino-3-nitropyridine

Downstream raw materials:

3-nitro-4-(phenylsulfonylmethyl)pyridine

3-nitro-6-(phenylsulfonylmethyl)pyridine

3-nitro-6-<1-(phenylsulfonyl)ethyl>pyridine

5-nitro-pyridin-2-ylamine

Refernces

• 1、 Kinarivala, Nihar,Trippier, Paul C.. "Exploration of relative chemoselectivity in the hydrodechlorination of 2-chloropyridines". supporting information. p. 5386 - 5389. Retrieved 2015/01/16.