Technology Process of N-(2-bromophenyl)-2-(4-methoxyphenyl)quinoline-4-carboxamide
There total 6 articles about N-(2-bromophenyl)-2-(4-methoxyphenyl)quinoline-4-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tantalum pentachloride; palladium dichloride;
In
2-methyltetrahydrofuran;
at 120 ℃;
for 12h;
chemoselective reaction;
Schlenk technique;
Inert atmosphere;
DOI:10.1039/c9cc00223e
- Guidance literature:
-
With
dmap;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 25 °C / 760.05 Torr
2.1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 - 25 °C / Inert atmosphere
3.1: pyridinium chlorochromate / dichloromethane / 2 h / 25 °C / Molecular sieve; Inert atmosphere
4.1: potassium tert-butylate / tetrahydrofuran; toluene / 3 h / 25 °C / Inert atmosphere
4.2: 2 h / 0 - 25 °C / Inert atmosphere
5.1: palladium dichloride; tantalum pentachloride / 2-methyltetrahydrofuran / 12 h / 120 °C / Schlenk technique; Inert atmosphere
With
lithium aluminium tetrahydride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; tantalum pentachloride; pyridinium chlorochromate; palladium dichloride;
In
tetrahydrofuran; 2-methyltetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
4.2: |Wittig Olefination;
DOI:10.1039/c9cc00223e