2-acetyl-3,5,6-trimethoxyphenyl acetate

Base Information

• Chemical Name: 2-acetyl-3,5,6-trimethoxyphenyl acetate
• CAS No.: 6953-31-7
• Molecular Formula: C13H16O6
• Molecular Weight: 268.2625
• Mol file: 6953-31-7.mol

Synonyms:

Chemical Property of 2-acetyl-3,5,6-trimethoxyphenyl acetate

Chemical Property:

• Vapor Pressure: 3.4E-06mmHg at 25°C
• Boiling Point: 387°C at 760 mmHg
• Flash Point: 171.1°C
• Density: 1.163g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-acetyl-3,5,6-trimethoxyphenyl acetate

There total 5 articles about 2-acetyl-3,5,6-trimethoxyphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

1,2,3,5-tetramethoxybenzene (5333-45-9) + acetyl chloride (75-36-5) → 1-(2,3,4,6-tetramethoxyphenyl)ethanone (7508-05-6) + 2'-acetoxy-3',4',5'-trimethoxyacetophenone (6953-31-7)

Guidance literature:

With In(OSO₂CF₃)3; at 75 - 90 ℃; for 0.1h; microwave irradiation;

DOI:10.3987/COM-03-9891

Reference yield:

2,6-dimethoxy-p-quinone (530-55-2,26547-64-8) → 2'-acetoxy-3',4',5'-trimethoxyacetophenone (6953-31-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / H₂ / Raney Ni / methanol / 20 °C

2: 84 percent / K₂CO₃ / acetone / 0.08 h / 73 °C / microwave irradiation

3: 6 percent / In(CF₃SO₃)3 / 0.1 h / 75 - 90 °C / microwave irradiation

With In(OSO₂CF₃)3; hydrogen; potassium carbonate; nickel; In methanol; acetone;

DOI:10.3987/COM-03-9891

Reference yield:

2,6-dimethoxy-1,4-hydroquinone (15233-65-5) → 2'-acetoxy-3',4',5'-trimethoxyacetophenone (6953-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / K₂CO₃ / acetone / 0.08 h / 73 °C / microwave irradiation

2: 6 percent / In(CF₃SO₃)3 / 0.1 h / 75 - 90 °C / microwave irradiation

With In(OSO₂CF₃)3; potassium carbonate; In acetone;

DOI:10.3987/COM-03-9891

upstream raw materials:

1-(2-hydroxy-3,4,6-trimethoxyphenyl)ethanone

acetic anhydride

1,2,3,5-tetramethoxybenzene

acetyl chloride

Downstream raw materials:

1-(2-hydroxy-3,4,6-trimethoxyphenyl)ethanone

1,2-dihydroxy-3,4,6-trimethoxybenzene

1-(2,3,4,5,6-pentamethoxyphenyl)ethan-1-one

1,2,3,4,5-pentamethoxybenzene

Refernces