1-(phenylamino)cyclopentanecarbonitrile

Base Information

• Chemical Name: 1-(phenylamino)cyclopentanecarbonitrile
• CAS No.: 6636-92-6
• Molecular Formula: C12H14 N2
• Molecular Weight: 186.257
• Mol file: 6636-92-6.mol

Synonyms:Cyclopentanecarbonitrile,1-anilino- (7CI,8CI); 1-Phenylaminocyclopentanecarbonitrile; NSC 52320

Chemical Property of 1-(phenylamino)cyclopentanecarbonitrile

Chemical Property:

• Vapor Pressure: 2.24E-05mmHg at 25°C
• Boiling Point: 360.3°Cat760mmHg
• Flash Point: 171.7°C
• Density: 1.08g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(phenylamino)cyclopentanecarbonitrile

There total 11 articles about 1-(phenylamino)cyclopentanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trimethylsilyl cyanide (7677-24-9) + cyclopentanone (120-92-3) + aniline (62-53-3) → 1-anilinocyclopentanecarbonitrile (6636-92-6)

Guidance literature:

With 1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; phenol; In toluene; at 40 ℃; Molecular sieve; Inert atmosphere;

DOI:10.1039/b924272d

Reference yield: 89.0%

Acetyl cyanide (631-57-2) + cyclopentanone (120-92-3) + aniline (62-53-3) → 1-anilinocyclopentanecarbonitrile (6636-92-6)

Guidance literature:

With N,N-dimethyl-cyclohexanamine; In water; at 20 ℃; for 24h;

DOI:10.1039/b914151k

Reference yield: 88.0%

1-amino-1-cyanocyclopentane (49830-37-7) + aniline (62-53-3) → 1-anilinocyclopentanecarbonitrile (6636-92-6)

Guidance literature:

In neat (no solvent); at 60 - 70 ℃;

DOI:10.1134/S1070428014010047

upstream raw materials:

1-hydroxycyclopentanecarbonitrile

aniline

N-(cyclopentylidene)aniline

potassium cyanide

Downstream raw materials:

spiro[cyclopentanyl-1',2-(5-imino-1-phenyl)pyrrolo(3,4-c)pyrazol(1H,2H)-5-one]

spiro[cyclopentanyl-1',2-(3-amino-1-phenyl)pyrazinolidin-6-one]

spiro[cyclopentanyl-1',2-(4-acetyl-3-amino-1-phenyl)pyrrol-5-one]

spiro[cyclopentanyl-1',3-(2-imino-7-methyl-4-phenyl)-1,4-oxazepin-5-one]

Refernces

• 1、 Gupta, Vijay,Mandal, Sanjay K.. "A microporous metal-organic framework catalyst for solvent-free strecker reaction and CO2 fixation at ambient conditions". . . Retrieved 2020/03/30.
• 2、 Baghery, Saeed,Zolfigol, Mohammad Ali,Schirhagl, Romana,Hasani, Masoumeh,Stuart, Marc C.A.,Nagl, Andreas. "Synthesis of novel magnetic nanoparticles with urea or urethane moieties: Applications as catalysts in the Strecker synthesis of α-aminonitriles". . . Retrieved 2017/10/03.