ethyl 1,2,3,4-tetrahydroisoquinolin-1-ylacetate

Base Information

• Chemical Name: ethyl 1,2,3,4-tetrahydroisoquinolin-1-ylacetate
• CAS No.: 1424-84-6
• Molecular Formula: C13H17 N O2
• Molecular Weight: 219.283
• Mol file: 1424-84-6.mol

Synonyms:Ethyl1,2,3,4-tetrahydroisoquinoline-1-acetate; NSC 351317

Chemical Property of ethyl 1,2,3,4-tetrahydroisoquinolin-1-ylacetate

Chemical Property:

• Vapor Pressure: 0.000201mmHg at 25°C
• Boiling Point: 327.5°Cat760mmHg
• Flash Point: 151.9°C
• Density: 1.062g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 1,2,3,4-tetrahydroisoquinolin-1-ylacetate

There total 11 articles about ethyl 1,2,3,4-tetrahydroisoquinolin-1-ylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3,4-dihydroisoquinoline (3230-65-7) + hydrogen ethyl malonate (1071-46-1) → 1-(ethoxycarbonylmethyl)-1,2,3,4-tetrahydroisoquinoline (1424-84-6)

Guidance literature:

at 120 ℃; for 1h;

DOI:10.1055/s-1987-33431

Reference yield: 72.0%

ethyl (E)-2-(2-phthalimidoethyl)cinnamate → 1-(ethoxycarbonylmethyl)-1,2,3,4-tetrahydroisoquinoline (1424-84-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 6h; Heating;

DOI:10.1021/jo00032a025

Reference yield: 66.0%

[PdBr2{2-(NH2CH2CH2)C6H4CH=CHCO2Et}2] → 1-(ethoxycarbonylmethyl)-1,2,3,4-tetrahydroisoquinoline (1424-84-6)

Guidance literature:

With 1,10-Phenanthroline; In dichloromethane; water; at 20 ℃; for 30h;

DOI:10.1021/om100738z

upstream raw materials:

3,4-dihydroisoquinoline

hydrogen ethyl malonate

ethyl 3,4-dihydroisoquinoline-1-acetate

2-phenylethyl chloride

Downstream raw materials:

1-(1,5-diaza-2,6-dioxocyclodecanyl)-1,2,3,4-tetrahydroisoquinoline

1,2,3,4,4a,6,7,13-octahydroisoquino<1,2-f>pyrido<2,1-b>pyrimidin-13-one

1,2,3,4,6,7,11b,12-octahydro-13H-isoquino<2,1-a><1,8>naphthylidin-13-one

2-(2-iodobenzoyl)-1-[3-(trimethylsilyl)prop-2-ynyl]-3,4-dihydro-1H-isoquinoline