2-METHYLAMINOPYRIDINE DIHYDROCHLORIDE

Base Information

• Chemical Name: 2-METHYLAMINOPYRIDINE DIHYDROCHLORIDE
• CAS No.: 84359-11-5
• Molecular Formula: C6H8 N2 . Cl H
• Molecular Weight: 0
• Mol file: 84359-11-5.mol

Synonyms:2-Pyridinemethanamine,monohydrochloride (9CI); (2-Pyridinylmethyl)amine hydrochloride

Chemical Property of 2-METHYLAMINOPYRIDINE DIHYDROCHLORIDE

Chemical Property:

• Melting Point: 209 - 212 °C
• PSA: 38.91000
• LogP: 2.04260

Purity/Quality:

99%min ^*data from raw suppliers

pyridin-2-ylmethanaminehydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYLAMINOPYRIDINE DIHYDROCHLORIDE

There total 7 articles about 2-METHYLAMINOPYRIDINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Cyanopyridine (100-70-9,1232006-36-8) → 2-(aminomethyl)pyridine hydrochloride (84359-11-5)

Guidance literature:

With hydrogenchloride; hydrogen; In 1,4-dioxane; methanol; at 60 ℃; for 18h; under 375.038 Torr; Flow reactor;

DOI:10.1002/open.201600166

Reference yield: 76.0%

4,4,5,5-tetramethyl-N-(pyridin-2-ylmethyl)-N-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3,2-dioxaborolan-2-amine → 2-(aminomethyl)pyridine hydrochloride (84359-11-5)

Guidance literature:

With hydrogenchloride; In water; at 25 ℃; for 2h; Temperature;

DOI:10.1021/jacs.5b08406

Reference yield: 74.5%

pyridine-2-carbaldehyde (1121-60-4) → (pyrid-2-yl)methylamine dihydrochloride (29968-84-1,50458-80-5,84359-11-5)

Guidance literature:

pyridine-2-carbaldehyde; With pyridoxal 5'-phosphate; ArRmut₁₁; isopropylamine; for 24h; Enzymatic reaction;

With hydrogenchloride; In diethyl ether; Reagent/catalyst;

DOI:10.1002/adsc.202100997

upstream raw materials:

2-(Aminomethyl)pyridine

2-(nitromethyl)pyridine

pyridine-2-carbaldehyde

2-hydroxyiminomethyl-pyridine

Downstream raw materials:

4-(4-methoxyphenyl)-3-(pyridine-2-ylmethyl)thiazol-2(3H)imine

3-(pyridine-2-ylmethyl)-4-p-tolylthiazol-2(3H)imine

4-phenyl-3-(pyridine-2-ylmethyl)thiazol-2(3H)imine

ethyl [(pyridin-2-ylmethyl)amino]acetate

Refernces

• 1、 Zhao, Lixing,Hu, Chenyang,Cong, Xuefeng,Deng, Gongda,Liu, Liu Leo,Luo, Meiming,Zeng, Xiaoming. "Cyclic (Alkyl)(amino)carbene Ligand-Promoted Nitro Deoxygenative Hydroboration with Chromium Catalysis: Scope, Mechanism, and Applications". supporting information. p. 1618 - 1629. Retrieved 2021/01/25.
• 2、 Fan, Guang-Gao,Jiang, Bo-Wen,Sang, Wei,Cheng, Hua,Zhang, Rui,Yu, Bao-Yi,Yuan, Ye,Chen, Cheng,Verpoort, Francis. "Metal-Free Synthesis of Heteroaryl Amines or Their Hydrochlorides via an External-Base-Free and Solvent-Free C-N Coupling Protocol". . p. 14627 - 14639. Retrieved 2021/11/01.