N-(2-Pyridylmethyl)glycine Ethyl Ester

Base Information

• Chemical Name: N-(2-Pyridylmethyl)glycine Ethyl Ester
• CAS No.: 62402-24-8
• Molecular Formula: C10H14N2O2
• Molecular Weight: 194.233
• Hs Code.: 2933399090
• European Community (EC) Number: 804-259-8
• DSSTox Substance ID: DTXSID30530865
• Nikkaji Number: J534.151E
• Wikidata: Q82402276
• Mol file: 62402-24-8.mol

Synonyms:62402-24-8;N-(2-Pyridylmethyl)glycine Ethyl Ester;Ethyl 2-((pyridin-2-ylmethyl)amino)acetate;ethyl 2-(pyridin-2-ylmethylamino)acetate;Ethyl N-(2-Pyridylmethyl)glycinate;ethyl 2-{[(pyridin-2-yl)methyl]amino}acetate;Glycine, N-(2-pyridinylmethyl)-, ethyl ester;SCHEMBL75805;DTXSID30530865;UCSBXEQEHOOKHG-UHFFFAOYSA-N;N-(2-Picolyl)glycine Ethyl Ester;MFCD00191573;AKOS000258016;SB53795;ethyl [(2-pyridinylmethyl)amino]acetate;N-(2-pyridylmethyl)-glycine ethyl ester;AS-65423;ethyl [(pyridin-2-ylmethyl)amino]acetate;Ethyl N-[(pyridin-2-yl)methyl]glycinate;N-(2-Pyridinylmethyl)-glycine ethyl ester;CS-0151571;P1194;T72721;EN300-7391837;A868478;N-(ethoxycarbonylmethyl)-N-(pyridin-2-ylmethyl)amine

Chemical Property of N-(2-Pyridylmethyl)glycine Ethyl Ester

Chemical Property:

• Refractive Index: 1.5050-1.5070
• Boiling Point: 285.663oC at 760 mmHg
• PKA: 5.40±0.20(Predicted)
• Flash Point: 126.565oC
• PSA: 51.22000
• Density: 1.1
• LogP: 1.12520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 194.105527694
• Heavy Atom Count: 14
• Complexity: 174

Purity/Quality:

97% ^*data from raw suppliers

N-(2-Pyridylmethyl)glycine Ethyl Ester ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CNCC1=CC=CC=N1

Technology Process of N-(2-Pyridylmethyl)glycine Ethyl Ester

There total 5 articles about N-(2-Pyridylmethyl)glycine Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(Aminomethyl)pyridine (3731-51-9) + ethyl bromoacetate (105-36-2) → ethyl [(pyridin-2-ylmethyl)amino]acetate (62402-24-8)

Guidance literature:

In tetrahydrofuran; at 0 ℃;

DOI:10.1039/b713664a

Reference yield: 69.0%

2-(Aminomethyl)pyridine (3731-51-9) + chloroacetic acid ethyl ester (105-39-5) → ethyl [(pyridin-2-ylmethyl)amino]acetate (62402-24-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 40 - 50 ℃;

Reference yield:

2-(aminomethyl)pyridine hydrochloride (84359-11-5) + chloroacetic acid ethyl ester (105-39-5) → ethyl [(pyridin-2-ylmethyl)amino]acetate (62402-24-8)

Guidance literature:

With triethylamine; In acetonitrile; at 20 - 50 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2008.12.021

upstream raw materials:

2-(Aminomethyl)pyridine

chloroacetic acid ethyl ester

ethyl bromoacetate

2-Cyanopyridine

Downstream raw materials:

octahydro-pyrido[1,2-a]pyrazin-4-one

2-(N-isopropyl-N-((2-pyridyl)methyl)aminomethyl)-6-(N-(ethoxycarbonylmethyl)-N-((2-pyridyl)methyl)aminomethyl)-4-methylphenol

diethyl 2,20-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis((pyridin-2-ylmethyl)azanediyl)diacetate

ethyl [(4-nitrobenzyl)(pyridin-2-ylmethyl)amino]acetate