(4-Aminophenoxy)acetic acid

Base Information

• Chemical Name: (4-Aminophenoxy)acetic acid
• CAS No.: 2298-36-4
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.164
• European Community (EC) Number: 218-947-5
• NSC Number: 36983
• UNII: RP5AG8F6UY
• DSSTox Substance ID: DTXSID60177525
• Nikkaji Number: J80.445B
• Wikidata: Q72440382
• ChEMBL ID: CHEMBL368851
• Mol file: 2298-36-4.mol

Synonyms:2-(4-aminophenoxy)acetic acid;2298-36-4;(4-Aminophenoxy)acetic acid;(p-Aminophenoxy)acetic acid;Acetic acid, (4-aminophenoxy)-;4-aminophenoxyacetic acid;acetic acid, 2-(4-aminophenoxy)-;RP5AG8F6UY;EINECS 218-947-5;NSC-36983;Acetic acid,2-(4-aminophenoxy)-;UNII-RP5AG8F6UY;ChemDiv2_003232;Oprea1_812941;2-(4-aminophenoxy)aceticacid;SCHEMBL655820;CHEMBL368851;Acetic acid, (p-aminophenoxy)-;NIOSH/AF3520000;DTXSID60177525;HMS1378C20;NSC36983;BBL013866;MFCD00224890;NSC 36983;STK500580;AKOS000103919;AS-38882;(4-amino-phenoxy)-acetic acid, AldrichCPR;AF35200000;CS-0199636;FT-0679420;M & B 2754;EN300-72963;A816456;SR-01000525559;SR-01000525559-1

Chemical Property of (4-Aminophenoxy)acetic acid

Chemical Property:

• Vapor Pressure: 4.99E-06mmHg at 25°C
• Melting Point: 132 °C
• Boiling Point: 366.868 °C at 760 mmHg
• PKA: 2.98±0.10(Predicted)
• Flash Point: 175.676 °C
• PSA: 72.55000
• Density: 1.317g/cm³
• LogP: 1.31340
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 167.058243149
• Heavy Atom Count: 12
• Complexity: 152

Purity/Quality:

99% ^*data from raw suppliers

2-(4-aminophenoxy)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1N)OCC(=O)O

Technology Process of (4-Aminophenoxy)acetic acid

There total 14 articles about (4-Aminophenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl 2-[4-[(tert-butoxycarbonyl)amino]phenoxy]acetate → 4-aminophenoxyacetic acid (2298-36-4)

Guidance literature:

With hydrogenchloride; at 60 ℃;

DOI:10.1039/c8ra02528b

Reference yield: 81.0%

(4-aminophenoxy)acetic acid hydrochloride → 4-aminophenoxyacetic acid (2298-36-4)

Guidance literature:

With potassium carbonate; In water; at 20 ℃; for 1h;

DOI:10.1080/00397911.2015.1041048

Reference yield:

4-acetaminophenol (103-90-2,8055-08-1) + sodium monochloroacetic acid (3926-62-3) → 4-aminophenoxyacetic acid (2298-36-4)

Guidance literature:

With sodium hydroxide; sodium carbonate; In hydrogenchloride; water;

upstream raw materials:

4-nitrophenoxyacetic acid

p-N-acetylaminophenoxyacetic acid

4-amino-phenol

bromoacetic acid

Downstream raw materials:

4-iodophenoxyacetic acid

ethyl 2-(4-aminophenoxy)acetate

(4-hydrazino-phenoxy)-acetic acid

[4-(3-p-Tolyl-propionylamino)-phenoxy]-acetic acid

Refernces

• 1、 Mokale, Santosh N.,Palkar, Akash D.,Dube, Pritam N.,Sakle, Nikhil S.,Miniyar, Pankaj B.. "Design, synthesis and in vivo screening of some novel quinazoline analogs as anti-hyperlipidemic and hypoglycemic agents". supporting information. p. 272 - 276. Retrieved 2016/01/09.
• 2、 -. "FUNCTIONALIZED PHENOLIC COMPOUNDS AND POLYMERS THEREFROM". Page/Page column 35; 37. . Retrieved 2009/07/17.