Quinfamide

Base Information

• Chemical Name: Quinfamide
• CAS No.: 62265-68-3
• Molecular Formula: C16H13Cl2NO4
• Molecular Weight: 354.19
• Hs Code.: 2934999090
• European Community (EC) Number: 263-478-1
• UNII: O1ZB1046R1
• DSSTox Substance ID: DTXSID90211320
• Nikkaji Number: J18.454C
• Wikipedia: Quinfamide
• Wikidata: Q21098930
• NCI Thesaurus Code: C72156
• Metabolomics Workbench ID: 153704
• ChEMBL ID: CHEMBL2107014
• Mol file: 62265-68-3.mol

Synonyms:quinfamide;Win 400 14

Chemical Property of Quinfamide

Chemical Property:

• Vapor Pressure: 3.37E-12mmHg at 25°C
• Melting Point: 145-146°C
• Refractive Index: 1.599
• Boiling Point: 551.3 °C at 760 mmHg
• PKA: -0.01±0.20(Predicted)
• Flash Point: 287.2 °C
• PSA: 59.75000
• Density: 1.428g/cm³
• LogP: 3.64670
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 353.0221633
• Heavy Atom Count: 23
• Complexity: 459

Purity/Quality:

98%,99%, ^*data from raw suppliers

QUINFAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(C=CC(=C2)OC(=O)C3=CC=CO3)N(C1)C(=O)C(Cl)Cl
• Recent ClinicalTrials: Study to Evaluate Efficacy and Safety of a Double Treatment Plan Using a Combination of Mebendazole and Quinfamide for Treating Intestinal Helminthiasis and Amebiasis in the Mexican Population
• Description: Quinfamide is an amebicide indicated for the one-day treatment of subacute or chronic intestinal amebiasis. It acts by rendering the trophozoites of E. histolytica incapable of propagation.
• Uses: Quinfamide is an anti-amebic agent used to treat tropical parasitic infections. An antiamebic agent, used to treat tropical parasitic infections

Technology Process of Quinfamide

There total 3 articles about Quinfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-furancarbonyl chloride (527-69-5) + 1-dichloroacetyl-1,2,3,4-tetrahydro-quinolin-6-ol (62265-67-2) + pyrographite (7440-44-0) → quinfamide (62265-68-3)

Guidance literature:

With acetic acid; triethylamine; In methanol; chloroform; ethyl acetate;

Reference yield:

6-hydroxy-1,2,3,4-tetrahydroquinoline (3373-00-0) → quinfamide (62265-68-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hexane; chloroform

2: acetic acid; triethylamine / methanol; chloroform; ethyl acetate

With acetic acid; triethylamine; In methanol; hexane; chloroform; ethyl acetate;

Reference yield:

→ quinfamide (62265-68-3)

Guidance literature:

Phenol (1), /BRN= 110144/;

DOI:10.1021/jm00191a031

upstream raw materials:

2-furancarbonyl chloride

1-dichloroacetyl-1,2,3,4-tetrahydro-quinolin-6-ol

pyrographite

6-hydroxy-1,2,3,4-tetrahydroquinoline

Refernces