4-BROMO-L-NAPHTHOL

Base Information

• Chemical Name: 4-BROMO-L-NAPHTHOL
• CAS No.: 571-57-3
• Molecular Formula: C10H7 Br O
• Molecular Weight: 223.069
• Hs Code.: 2908199090
• Mol file: 571-57-3.mol

Synonyms:1-Naphthol,4-bromo- (7CI,8CI); 4-Bromo-1-naphthol; 4-Bromo-a-naphthol; 4-Bromonaphthalen-1-ol

Chemical Property of 4-BROMO-L-NAPHTHOL

Chemical Property:

• Melting Point: 128-133°C
• Boiling Point: 346.4±15.0 °C(Predicted)
• PKA: 8.95±0.40(Predicted)
• Flash Point: 125℃
• PSA: 20.23000
• Density: 1.614
• LogP: 3.30790
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-1-naphthalenol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 21/22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-L-NAPHTHOL

There total 26 articles about 4-BROMO-L-NAPHTHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

α-naphthol (90-15-3) → 4-bromo-1-naphthol (571-57-3) + 2,4-dibromo-1-naphthol (2050-49-9)

Guidance literature:

With bis(trichloromethyl) carbonate; tetrabutylammomium bromide; potassium bromide; In 1,2-dichloro-ethane; at 40 ℃;

Reference yield: 96.0%

α-naphthol (90-15-3) → 4-bromo-1-naphthol (571-57-3)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 3.5h;

DOI:10.1021/jo100053j

Reference yield: 90.0%

trans,trans,trans-2,3,4-tribromo-1-hydroxytetralin → 4-bromo-1-naphthol (571-57-3)

Guidance literature:

at 20 ℃; for 336000h;

upstream raw materials:

t-butyl bromide

α-naphthol

1-bromo-4-methoxynaphthalene

4-hydroxy-1-naphthoic acid

Downstream raw materials:

4-bromo-1-ethoxynaphthalene

1-(4-bromo-1-hydroxynaphthalen-2-yl)ethanone

3,4-dihydro-2H-pyran

(4-bromonaphthalen-1-yloxy)(tert-butyl)dimethylsilane

Refernces

• 1、 Albadi, Jalal,Jalali, Mehdi. "New procedure for the highly regioselective aerobic bromination of aromatic compounds using copper-based nanocatalyst". . p. 234 - 239. Retrieved 2020/02/29.
• 2、 -. "COMPOUNDS FOR THE INHIBITION OF UNREGULATED CELL GROWTH". Page/Page column 28-29; 40. . Retrieved 2020/07/14.