2-Bromo-2-methylpropane

Base Information

• Chemical Name: 2-Bromo-2-methylpropane
• CAS No.: 507-19-7
• Molecular Formula: C4H9Br
• Molecular Weight: 137.019
• Hs Code.: 29033036
• European Community (EC) Number: 208-065-9
• NSC Number: 8418
• UN Number: 2342
• UNII: 5LWO08435U
• DSSTox Substance ID: DTXSID5060144
• Nikkaji Number: J409J
• Wikipedia: Tert-Butyl_bromide
• Wikidata: Q256982
• ChEMBL ID: CHEMBL347644
• Mol file: 507-19-7.mol

Synonyms:2-Bromo-2-methylpropane;tert-Butyl bromide;507-19-7;T-BUTYL BROMIDE;Trimethylbromomethane;2-Bromoisobutane;Propane, 2-bromo-2-methyl-;Bromotrimethylmethane;tert-butylbromide;Tertiarybutyl bromide;1-Bromo-1,1-dimethylethane;2-methyl-2-bromopropane;2-Bromo-2-methylpropane-d9;2-Bromo-2-methyl-propane;1,1-Dimethylethyl chloride;NSC 8418;CCRIS 107;HSDB 2196;EINECS 208-065-9;UNII-5LWO08435U;5LWO08435U;NSC-8418;1,1-Dimethylethyl bromide;tertbutylbromide;tertbutyl bromide;tert. butylbromide;tert.-butylbromide;tert.butyl bromide;Butylbromide, tert-;MFCD00000125;tert-C4H9Br;tertiary-butyl bromide;2-bromo-2methyl-propane;2-Bromo-2-methyl propane;2-bromanyl-2-methyl-propane;SCHEMBL22538;BUTYL BROMIDE, TERT-;CHEMBL347644;T-BUTYL BROMIDE [HSDB];DTXSID5060144;TERT-BUTYL BROMIDE [MI];2-Bromo-2-methylpropane, 98%;NSC8418;WLN: EX1&1&1;STR04155;NA2342;STL282745;UN2342;AKOS009031116;BP-31078;LS-119650;B0617;FT-0611397;EN300-21275;A828265;Q256982;2-Bromo-2-methylpropane, purum, >=97.0% (GC);W-105932;F0001-1326;tert-Butyl bromide, 98+%, stab. with potassium carbonate

Chemical Property of 2-Bromo-2-methylpropane

Chemical Property:

• Appearance/Colour: clear colourless to yellow-brown liquid
• Vapor Pressure: 126mmHg at 25°C
• Melting Point: -20 °C
• Refractive Index: n20/D 1.4279(lit.)
• Boiling Point: 73.2 °C at 760 mmHg
• Flash Point: 18.3 °C
• PSA: 0.00000
• Density: 1.271 g/cm³
• LogP: 2.17980
• Storage Temp.: Flammables area
• Solubility.: H2O: insoluble
• Water Solubility.: insoluble
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 135.98876
• Heavy Atom Count: 5
• Complexity: 25.1
• Transport DOT Label: Flammable Liquid

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-2-methylpropane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xi
• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-33-37/39-26

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Halogenated Aliphatics, Saturated
• Canonical SMILES: CC(C)(C)Br
• Uses: tert-Butyl bromide is used as a raw material in synthetic organic chemistry. It is used to study the massive deadenylation of adenine based-nucleosides. 2-Bromo-2-methylpropane was used to study the massive deadenylation of adenine based-nucleosides induced by halogenated alkanes under physiological conditions.

Technology Process of 2-Bromo-2-methylpropane

There total 68 articles about 2-Bromo-2-methylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tertiary butyl chloride (507-20-0) → t-butyl bromide (507-19-7)

Guidance literature:

With hydrogen bromide; ferric(III) bromide; In dichloromethane; at 25 ℃; for 0.2h;

DOI:10.1039/c39870001013

Reference yield: 98.0%

tert-Butyl iodide (558-17-8) → t-butyl bromide (507-19-7)

Guidance literature:

With bismuth(III) bromide; In dichloromethane; at 25 ℃; for 1.75h;

DOI:10.1016/S0040-4020(98)01213-7

Reference yield: 97.0%

s-butyl chloride (78-86-4,53178-20-4) → t-butyl bromide (507-19-7) + s-butyl bromide (78-76-2,5787-31-5)

Guidance literature:

With hydrogen bromide; ferric(III) bromide; In dichloromethane; at 25 ℃; for 15h;

DOI:10.1039/c39870001013

upstream raw materials:

tertiary butyl chloride

Isobutyl bromide

1,2-dibromo-2-methyl-propane

di-tert-butyl peroxide

Downstream raw materials:

1,4-dibromo-butane

4,4'-dibromo-di-n-butyl ether

isobutene

Isobutyl bromide

Refernces

• 1、 Peeters,Anteunis. "". . p. 312,313. Retrieved 1975.
• 2、 Brunel. "-". . p. 1978. Retrieved 1917.
• 3、 Kharasch,Hinckley. "-". . p. 1243. Retrieved 1934.
• 4、 Eckstein et al.. "". . p. 28,35. Retrieved 1954.
• 5、 Phuc Tran, Dat,Nomoto, Akihiro,Mita, Soichiro,Dong, Chun-ping,Kodama, Shintaro,Mizuno, Takumi,Ogawa, Akiya. "Metal- and base-free synthesis of aryl bromides from arylhydrazines". supporting information. . Retrieved 2020/05/08.
• 6、 Munyemana, Fran?ois,George, Isabelle,Devos, Alain,Colens, Alain,Badarau, Eduard,Frisque-Hesbain, Anne-Marie,Loudet, Aurore,Differding, Edmond,Damien, Jean-Marie,Rémion, Jeanine,Van Uytbergen, Jacqueline,Ghosez, Léon. "A mild method for the replacement of a hydroxyl group by halogen. 1. Scope and chemoselectivity". . p. 420 - 430. Retrieved 2015/12/31.