Carbamic acid, (5-amino-1,2-dihydro-3-(4-(trifluoromethyl)phenyl)pyrid o(3,4-b)pyrazin-7-yl)-, ethyl ester

Base Information

• Chemical Name: Carbamic acid, (5-amino-1,2-dihydro-3-(4-(trifluoromethyl)phenyl)pyrid o(3,4-b)pyrazin-7-yl)-, ethyl ester
• CAS No.: 82586-03-6
• Molecular Formula: C17H16F3N5O2
• Molecular Weight: 379.3364
• Mol file: 82586-03-6.mol

Synonyms:ETHYL N-[5-AMINO-8-[4-(TRIFLUOROMETHYL)PHENYL]-4,7,10-TRIAZABICYCLO[4.4.0]DECA-1,3,5,7-TETRAEN-3-YL]CARBAMATE;Ethyl (5-amino-1,2-dihydro-3-(4-(trifluoromethyl)phenyl)pyrido(3,4-b)pyrazin-7-yl)carbamate;Carbamic acid,(5-amino-1,2-dihydro-3-(4-(trifluoromethyl)phenyl)pyrido(3,4-b)pyrazin-7-yl)-,ethyl ester;

Chemical Property of Carbamic acid, (5-amino-1,2-dihydro-3-(4-(trifluoromethyl)phenyl)pyrid o(3,4-b)pyrazin-7-yl)-, ethyl ester

Chemical Property:

• Vapor Pressure: 2.58E-09mmHg at 25°C
• Boiling Point: 478.4°Cat760mmHg
• Flash Point: 243.1°C
• PSA: 105.12000
• Density: 1.49g/cm³
• LogP: 3.96570

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (5-amino-1,2-dihydro-3-(4-(trifluoromethyl)phenyl)pyrid o(3,4-b)pyrazin-7-yl)-, ethyl ester

There total 4 articles about Carbamic acid, (5-amino-1,2-dihydro-3-(4-(trifluoromethyl)phenyl)pyrid o(3,4-b)pyrazin-7-yl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Amino-1-(4-trifluoromethyl-phenyl)-ethanone oxime (82585-42-0) → [5-Amino-3-(4-trifluoromethyl-phenyl)-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl]-carbamic acid ethyl ester (82586-03-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 47 percent / Et₃N / ethanol / 2 h / 75 °C

2: 31 percent / 1N aq. HCl / dioxane / 2 h / 60 °C

3: 56 percent / H₂ / Raney nickel / ethanol; dioxane / 48 h / 760 Torr / Heating

With hydrogenchloride; hydrogen; triethylamine; nickel; In 1,4-dioxane; ethanol;

DOI:10.1021/jm00351a008

Reference yield:

ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate (6506-86-1) → [5-Amino-3-(4-trifluoromethyl-phenyl)-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl]-carbamic acid ethyl ester (82586-03-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 47 percent / Et₃N / ethanol / 2 h / 75 °C

2: 31 percent / 1N aq. HCl / dioxane / 2 h / 60 °C

3: 56 percent / H₂ / Raney nickel / ethanol; dioxane / 48 h / 760 Torr / Heating

With hydrogenchloride; hydrogen; triethylamine; nickel; In 1,4-dioxane; ethanol;

DOI:10.1021/jm00351a008

Reference yield:

2-[2-[(E)-Hydroxyimino]-2-(4-trifluoromethyl-phenyl)-ethyl]-isoindole-1,3-dione (82585-55-5) → [5-Amino-3-(4-trifluoromethyl-phenyl)-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl]-carbamic acid ethyl ester (82586-03-6)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrazine / ethanol / 22 h / 40 °C

2: 47 percent / Et₃N / ethanol / 2 h / 75 °C

3: 31 percent / 1N aq. HCl / dioxane / 2 h / 60 °C

4: 56 percent / H₂ / Raney nickel / ethanol; dioxane / 48 h / 760 Torr / Heating

With hydrogenchloride; hydrogen; triethylamine; hydrazine; nickel; In 1,4-dioxane; ethanol;

DOI:10.1021/jm00351a008

upstream raw materials:

ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate

2-Amino-1-(4-trifluoromethyl-phenyl)-ethanone oxime

2-[2-[(E)-Hydroxyimino]-2-(4-trifluoromethyl-phenyl)-ethyl]-isoindole-1,3-dione

{6-Amino-4-[2-[(Z)-hydroxyimino]-2-(4-trifluoromethyl-phenyl)-ethylamino]-5-nitro-pyridin-2-yl}-carbamic acid ethyl ester

Downstream raw materials:

ethyl 5-amino-3-[4-(trifluoromethyl)phenyl]pyrido[3,4-b]pyrazine-7-carbamate