Brovincamine

Base Information

Chemical Name:Brovincamine
CAS No.:57475-17-9
Molecular Formula:C₂₁H₂₅BrN₂O₃
Molecular Weight:433.345
Hs Code.:
UNII:AYN5T18K5R
DSSTox Substance ID:DTXSID701024133
Nikkaji Number:J14.541F
Wikidata:Q27274193
NCI Thesaurus Code:C74419
ChEMBL ID:CHEMBL165643
Mol file:57475-17-9.mol

Synonyms:11-bromovincamine;11-bromovincamine fumarate (1:1);bromovincamine fumarate;brovincamine

Suppliers and Price of Brovincamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
11-BROMOVINCAMINE 95.00%
5MG
$ 499.60

Total 12 raw suppliers

Chemical Property of Brovincamine

Chemical Property:

Vapor Pressure:7.7E-13mmHg at 25°C
Melting Point:214° (dec)
Boiling Point:547.9°Cat760mmHg
Flash Point:285.2°C
PSA：54.70000
Density:1.59g/cm³
LogP:3.65290
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:432.10486
Heavy Atom Count:27
Complexity:633

Purity/Quality:

99% up by HPLC ^*data from raw suppliers

11-BROMOVINCAMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC12CCCN3C1C4=C(CC3)C5=C(N4C(C2)(C(=O)OC)O)C=C(C=C5)Br
Isomeric SMILES:CC[C@@]12CCCN3[C@@H]1C4=C(CC3)C5=C(N4[C@](C2)(C(=O)OC)O)C=C(C=C5)Br
Uses Brovincamine is a useful reagent for the synthesis of Vincamine (V314030(P)), which is used for the treatment of cerebral insufficiencies.

Technology Process of Brovincamine

There total 6 articles about Brovincamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (+)-3(S),17(S)-11-Bromo-14-oxo-15-hydroxyimino-E-homo-eburnane hydrochloride

: 57475-17-9
(+)-11-bromovincamine

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / p-TsOH, paraformaldehyde / acetic acid / 3 h / 110 - 115 °C

2: t-BuOK / 2 h / Ambient temperature

With formaldehyd; potassium tert-butylate; toluene-4-sulfonic acid; In acetic acid;
DOI:10.1002/ardp.19873200904