Benzenepropanoic acid,2-[[5-[(Z)-(1,5- dihydro-3,4-dimethyl-5-oxo-2H-pyrrol-2- ylidene)methyl]-3,4-dimethyl-1H-pyrrol-2-yl]- methyl]-

Base Information

• Chemical Name: Benzenepropanoic acid,2-[[5-[(Z)-(1,5- dihydro-3,4-dimethyl-5-oxo-2H-pyrrol-2- ylidene)methyl]-3,4-dimethyl-1H-pyrrol-2-yl]- methyl]-
• CAS No.: 205056-02-6
• Molecular Formula: C₂₃H₂₆N₂O₃
• Molecular Weight: 378.471
• Mol file: 205056-02-6.mol

Synonyms:

Chemical Property of Benzenepropanoic acid,2-[[5-[(Z)-(1,5- dihydro-3,4-dimethyl-5-oxo-2H-pyrrol-2- ylidene)methyl]-3,4-dimethyl-1H-pyrrol-2-yl]- methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanoic acid,2-[[5-[(Z)-(1,5- dihydro-3,4-dimethyl-5-oxo-2H-pyrrol-2- ylidene)methyl]-3,4-dimethyl-1H-pyrrol-2-yl]- methyl]-

There total 6 articles about Benzenepropanoic acid,2-[[5-[(Z)-(1,5- dihydro-3,4-dimethyl-5-oxo-2H-pyrrol-2- ylidene)methyl]-3,4-dimethyl-1H-pyrrol-2-yl]- methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

3-(2-{5-[3,4-Dimethyl-5-oxo-1,5-dihydro-pyrrol-(2Z)-ylidenemethyl]-3,4-dimethyl-1H-pyrrole-2-carbonyl}-phenyl)-propionic acid methyl ester (204994-94-5) → 3-(2-{5-[3,4-Dimethyl-5-oxo-1,5-dihydro-pyrrol-(2Z)-ylidenemethyl]-3,4-dimethyl-1H-pyrrol-2-ylmethyl}-phenyl)-propionic acid (205056-02-6)

Guidance literature:

With potassium borohydride; In isopropyl alcohol; for 2h; Heating;

DOI:10.1021/jo972227r

Reference yield:

2-(2-methoxycarbonylethyl)benzoic acid (33779-03-2) → 3-(2-{5-[3,4-Dimethyl-5-oxo-1,5-dihydro-pyrrol-(2Z)-ylidenemethyl]-3,4-dimethyl-1H-pyrrol-2-ylmethyl}-phenyl)-propionic acid (205056-02-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / thionyl chloride / 0.17 h / 50 °C

2: 95 percent / tin tetrachloride / CH₂Cl₂ / 1.) 0 deg C, 20 min, 2.) room temperature, 2 h

3: 63 percent / potassium borohydride / propan-2-ol / 2 h / Heating

With thionyl chloride; potassium borohydride; tin(IV) chloride; In dichloromethane; isopropyl alcohol;

DOI:10.1021/jo972227r

Reference yield:

2-(2-carboxyethyl)benzoic acid (776-79-4) → 3-(2-{5-[3,4-Dimethyl-5-oxo-1,5-dihydro-pyrrol-(2Z)-ylidenemethyl]-3,4-dimethyl-1H-pyrrol-2-ylmethyl}-phenyl)-propionic acid (205056-02-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / 0.5 h / Ambient temperature

2: 66 percent / thionyl chloride / 0.17 h / 50 °C

3: 95 percent / tin tetrachloride / CH₂Cl₂ / 1.) 0 deg C, 20 min, 2.) room temperature, 2 h

4: 63 percent / potassium borohydride / propan-2-ol / 2 h / Heating

With thionyl chloride; potassium borohydride; sulfuric acid; tin(IV) chloride; In dichloromethane; isopropyl alcohol;

DOI:10.1021/jo972227r

upstream raw materials:

3-(2-{5-[3,4-Dimethyl-5-oxo-1,5-dihydro-pyrrol-(2Z)-ylidenemethyl]-3,4-dimethyl-1H-pyrrole-2-carbonyl}-phenyl)-propionic acid methyl ester

2-(2-methoxycarbonylethyl)benzoic acid

2-(2-carboxyethyl)benzoic acid

(E)-o-carboxycinnamic acid