1-(3,4-METHYLENEDIOXYPHENYL)ETHANOL

Base Information

• Chemical Name: 1-(3,4-METHYLENEDIOXYPHENYL)ETHANOL
• CAS No.: 6329-73-3
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.177
• Hs Code.: 2932999099
• Mol file: 6329-73-3.mol

Synonyms:Piperonylalcohol, a-methyl- (6CI,7CI,8CI);1-(3,4-Methylenedioxyphenyl)ethanol; 1-(Benzodioxol-5-yl)ethanol;5-(1-Hydroxyethyl)-1,3-benzodioxole; NSC 6988

Chemical Property of 1-(3,4-METHYLENEDIOXYPHENYL)ETHANOL

Chemical Property:

• Vapor Pressure: 0.00214mmHg at 25°C
• Boiling Point: 277.7°C at 760 mmHg
• Flash Point: 121.7°C
• PSA: 38.69000
• Density: 1.261g/cm³
• LogP: 1.46860
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-(2H-1,3-benzodioxol-5-yl)ethan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3,4-METHYLENEDIOXYPHENYL)ETHANOL

There total 9 articles about 1-(3,4-METHYLENEDIOXYPHENYL)ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

piperonal (120-57-0,30024-74-9) + methyl iodide (74-88-4) → 1-benzo[1,3]dioxol-5-yl-ethanol (6329-73-3,91613-73-9,120523-14-0)

Guidance literature:

methyl iodide; With magnesium; In diethyl ether; at 0 - 5 ℃;

piperonal; In diethyl ether;

DOI:10.1016/j.tetasy.2005.07.009

Reference yield: 95.0%

1-(benzo[d][1,3]dioxol-6-yl)ethanone (3162-29-6) → 1-benzo[1,3]dioxol-5-yl-ethanol (6329-73-3,91613-73-9,120523-14-0)

Guidance literature:

With sodium tetrahydridoborate; In methanol; dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1002/chem.200601764

Reference yield: 93.0%

methyl bromide (74-83-9) + piperonal (120-57-0,30024-74-9) → 1-benzo[1,3]dioxol-5-yl-ethanol (6329-73-3,91613-73-9,120523-14-0)

Guidance literature:

methyl bromide; With magnesium; In diethyl ether;

piperonal; In diethyl ether; for 0.5h;

upstream raw materials:

methyl magnesium iodide

piperonal

methyl iodide

1-(benzo[d][1,3]dioxol-6-yl)ethanone

Downstream raw materials:

1-(benzo[d][1,3]dioxol-6-yl)ethanone

1-(2′-bromo-4′,5′-methylenedioxyphenyl)ethan-1-ol

dimethyl 9-(4-fluorophenyl)-6-methylnaphtho[1,2-d]-1,3-dioxole-7,8-dicarboxylate

2-(1-benzo[1,3]dioxol-5-yl-ethoxy)-6-fluorobenzonitrile

Refernces

• 1、 Nishimoto, Yoshihiro,Wang, Fei,Yasuda, Makoto. "Indium-Catalyzed Formal Carbon-Halogen Bond Insertion: Synthesis of α-Halo-α,α-disubstituted Esters from Benzylic Halides and Diazo Esters". supporting information. p. 1706 - 1710. Retrieved 2022/03/14.
• 2、 Jia, Wei-Guo,Zhi, Xue-Ting,Li, Xiao-Dong,Zhou, Jun-Peng,Zhong, Rui,Yu, Haibo,Lee, Richmond. "Postsynthetic Modification of Half-Sandwich Ruthenium Complexes by Mechanochemical Synthesis". . p. 4313 - 4321. Retrieved 2021/05/04.