N1-METHYL-2'-DEOXYGUANOSINE

Base Information

• Chemical Name: N1-METHYL-2'-DEOXYGUANOSINE
• CAS No.: 5132-79-6
• Molecular Formula: C11H15 N5 O4
• Molecular Weight: 281.271
• Mol file: 5132-79-6.mol

Synonyms:1-Methyl-2'-deoxyguanosine;N1-Methyl-2'-deoxyguanosine; NSC 70899

Chemical Property of N1-METHYL-2'-DEOXYGUANOSINE

Chemical Property:

• Vapor Pressure: 5.01E-20mmHg at 25°C
• Boiling Point: 690.7°Cat760mmHg
• Flash Point: 371.5°C
• PSA: 128.42000
• Density: 1.88g/cm³
• LogP: -1.06590
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

N1-Methyl-2’-deoxyguanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N1-Methyl-2’-deoxyguanosine is a model for alkylation of DNA. Also, it is formed from the reaction of 2’-Deoxyguanosine with N-Nitroso-N-methyl-N’-phenylurea in methanol.

Technology Process of N1-METHYL-2'-DEOXYGUANOSINE

There total 2 articles about N1-METHYL-2'-DEOXYGUANOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-1-nitrosourea (684-93-5) + 2'-Deoxyguanosine (961-07-9) → 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine (964-21-6,52225-08-8) + N1-methyl-2'-deoxyguanosine (5132-79-6) + methylphosphate (812-00-0) + dimethylphosphoric acid (813-78-5) + 7-methylguanine (578-76-7) + N7-Me-dGuo (28074-91-1)

Guidance literature:

With sodium hydroxide; phosphate buffer; In methanol; water; at 37 ℃; Product distribution; various pH values;

DOI:10.1016/S0040-4020(97)00018-5

Reference yield:

trimethylsulphonium hydroxide (17287-03-5) + 2'-Deoxyguanosine (961-07-9) → 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine (964-21-6,52225-08-8) + N1-methyl-2'-deoxyguanosine (5132-79-6) + 7-Methyl-2'-deoxyguanosine (107149-64-4) + 9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1-methyl-2-methylamino-1,9-dihydro-purin-6-one (76551-24-1)

Guidance literature:

In methanol; N,N-dimethyl-formamide; at 70 ℃; for 1h; Further byproducts given;

upstream raw materials:

trimethylsulphonium hydroxide

2'-Deoxyguanosine

1-methyl-1-nitrosourea

Refernces

• 1、 Yamauchi, Kiyoshi,Nakagima, Toru,Kinoshita, Masayoshi. "Methylation study of ribonucleosides, deoxyribonucleosides, and 2′-O-methylribonucleosides with trimethylsulphonium hydroxide and trimethylsulphonium iodide. Influence of the 2′-hydroxy-groups on the reactivity of the base moieties of ribonucleosides". . p. 2787 - 2792. Retrieved 2007/10/02.