812-00-0

Basic information

• Product Name: methyl dihydrogen phosphate
• Synonyms: methyl dihydrogen phosphate;Phosphoric acid, monomethyl ester;MONOMETHYLPHOSPHATE;Phosphoric acid dihydrogen methyl ester
• CAS NO: 812-00-0
• Molecular Formula: CH₅O₄P
• Molecular Weight: 112.021761
• EINECS: 212-379-1
• Mol File: 812-00-0.mol
• Article Data: 32

Chemical Properties

• Boiling Point: 250.086°C at 760 mmHg
• Flash Point: 105.048°C
• Appearance: /
• Density: 1.587±0.06 g/cm3(Predicted)
• Vapor Pressure: 0.007mmHg at 25°C
• PKA: 1.81±0.10(Predicted)
• Water Solubility: 435g/L at 25℃
• CAS DataBase Reference: methyl dihydrogen phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl dihydrogen phosphate(812-00-0)
• EPA Substance Registry System: methyl dihydrogen phosphate(812-00-0)

Safety Data

• RIDADR: 3265
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 812-00-0(Hazardous Substances Data)

Usage

Description

Methyl dihydrogen phosphate, also known as monomethyl phosphate, is a monoalkyl phosphate epitope with a methyl group as the alkyl group. It is a clear, very light amber liquid and serves as a useful building block and byproduct of the degradation of black phosphorous in protic solvents.

Uses

Used in Chemical Synthesis:
Methyl dihydrogen phosphate is used as a building block in chemical synthesis for various applications, including the production of other organic compounds and materials.
Used in Research and Development:
Methyl dihydrogen phosphate is used as a research compound to study the properties and reactions of monoalkyl phosphates, which can contribute to the development of new chemical processes and applications.
Used in Protic Solvent Degradation:
Methyl dihydrogen phosphate is used as a byproduct in the degradation of black phosphorous in protic solvents, which can be further utilized in various chemical processes and applications.

Air & Water Reactions

Water soluble.

Reactivity Profile

Susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. Can be neutralized with alkalis or amines to give water-soluble salts.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition methyl dihydrogen phosphate emits toxic fumes of phosphorous oxides.

Fire Hazard

methyl dihydrogen phosphate is probably combustible.

InChI:InChI=1/CH5O4P/c1-5-6(2,3)4/h1H3,(H2,2,3,4)/p-2

Upstream product

• 67-56-1 methanol 
• 1571-33-1 phenylphosphonate 
• 93-89-0 benzoic acid ethyl ester 
• 799-87-1 bis(p-nitrophenyl) methyl phosphate 
• 10025-87-3 trichlorophosphate 
• 114142-42-6 (E)-α-hydroxyiminobenzylphosphonic acid monomethyl ester 
• 67-63-0 isopropyl alcohol 
• 78-92-2 iso-butanol 
• 756-79-6 dimethyl methane phosphonate 
• 77815-88-4 C₅H₁₂NO₅P 
• 62-73-7 Dichlorvos 
• 950-35-6 methyl paraoxon 
• 681-84-5 tetramethylorthosilicate 
• 86119-84-8 phosphoric acid 

Downstream Products

• 67-56-1 methanol 
• 26644-00-8 P¹,P²-Dimethyl diphosphate 
• 57-00-1 Creatinine 

Relevant articles and documents

-

-

Loci of ceric cation mediated hydrolyses of dimethyl phosphate and methyl methylphosphonate

(formula presented) Dimethyl phosphate and methyl methylphosphonate are cleaved by Ce(IV)-mediated hydrolysis with 91% and 88% P-O scission, respectively, and rate accelerations of ≥ 1010 relative to pH 7 P-O hydrolysis.

METHOD FOR PRODUCING PHOSPHOESTER COMPOUND

PROBLEM TO BE SOLVED: To provide a method whereby, a phosphate compound selected from the group consisting of orthophosphoric acid, phosphonic acid, phosphinic acid, and anhydrides of them is used as raw material and, by one stage reaction, a corresponding phosphoester compound is produced. SOLUTION: To an aqueous solution of a phosphate compound, added is an organic silane or siloxane compound having an alkoxy group or an aryloxy group, and the mixture is subjected to a heating reaction, thereby producing a corresponding phosphoester compound without requiring a catalyst. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

A Light-Releasable Potentially Prebiotic Nucleotide Activating Agent

Investigations into the chemical origin of life have recently benefitted from a holistic approach in which possible atmospheric, organic, and inorganic systems chemistries are taken into consideration. In this way, we now report that a selective phosphate activating agent, namely methyl isocyanide, could plausibly have been produced from simple prebiotic feedstocks. We show that methyl isocyanide drives the conversion of nucleoside monophosphates to phosphorimidazolides under potentially prebiotic conditions and in excellent yields for the first time. Importantly, this chemistry allows for repeated reactivation cycles, a property long sought in nonenzymatic oligomerization studies. Further, as the isocyanide is released upon irradiation, the possibility of spatially and temporally controlled activation chemistry is thus raised.

Method for preparing monoalkyl hypophosphite

The invention relates to a method for preparing monoalkyl hypophosphite. The method comprises the steps of oxidizing monoalkyl hydrogen phosphide halate solution by virtue of hydrogen peroxide, wherein the molar ratio of the monoalkyl hydrogen phosphide halate solution to hydrogen peroxide is 1 to 2 or 1 to 2.1, and the reaction temperature is between (-50)-(20) DEG C. The molecular formula of monoalkyl hypophosphite is RP(H)OOH, wherein R is C1-C10 straight-chain, branched-chain alkyl groups. The method for preparing monoalkyl hypophosphite has the beneficial effects that the reaction yield is more than 80%, and water and halogen hydride can be easily evaporated at a reduced pressure after the reaction is finished and can be recycled by virtue of a sodium hydroxide solution and are not the main content of the invention, so that the method described by the invention is safe, environment-friendly and economic.