2-Cyclohexyl-2-phenylacetaldehyde

Base Information

• Chemical Name: 2-Cyclohexyl-2-phenylacetaldehyde
• CAS No.: 5664-22-2
• Molecular Formula: C25H23BrN2O5S
• Molecular Weight: 202.296
• Mol file: 5664-22-2.mol

Synonyms:SCHEMBL193457

Chemical Property of 2-Cyclohexyl-2-phenylacetaldehyde

Chemical Property:

• Vapor Pressure: 8.14E-16mmHg at 25°C
• Boiling Point: 630.7°Cat760mmHg
• Flash Point: 335.2°C
• Density: 1.45g/cm³
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 202.135765193
• Heavy Atom Count: 15
• Complexity: 188

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)C(C=O)C2=CC=CC=C2

Technology Process of 2-Cyclohexyl-2-phenylacetaldehyde

There total 16 articles about 2-Cyclohexyl-2-phenylacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-cyclohexyl-2-phenyloxirane (144313-98-4) → (+/-)-2-cyclohexyl-2-phenylacetaldehyde (5664-22-2)

Guidance literature:

With C₃₆H₅₄IrNP⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); In tetrahydrofuran; at 23 - 100 ℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1039/c4cc05260a

Reference yield: 76.0%

cyclohexyl phenyl acetonitrile (3893-23-0) → (+/-)-2-cyclohexyl-2-phenylacetaldehyde (5664-22-2)

Guidance literature:

With sodium hydride; zinc(II) chloride; In tetrahydrofuran; mineral oil; at 40 ℃; for 4h; Inert atmosphere; Sealed tube;

DOI:10.1055/s-0039-1690838

Reference yield: 54.0%

(cyclohexyl(phenyl)methyl)(phenyl)sulfide + N,N-dimethyl-formamide (68-12-2,33513-42-7) → (+/-)-2-cyclohexyl-2-phenylacetaldehyde (5664-22-2)

Guidance literature:

(cyclohexyl(phenyl)methyl)(phenyl)sulfide; With lithium naphthalenide; In tetrahydrofuran; at -78 - -20 ℃; for 3h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -20 - 20 ℃; for 14h; Inert atmosphere;

DOI:10.1002/anie.201709715

upstream raw materials:

cyclohexyl-phenyl-acetyl chloride

benzene

2-cyclohexyl-2-phenylethan-1-ol

2-cyclohexyl-2-phenylacetic acid

Downstream raw materials:

Cyclohexyl phenyl ketone

(Z)-3-(2-phenyl-2-cyclohexyl)oxazolidin-2-one

(cyclohexylmethyl)benzene

2-cyclohexyl-2-phenylacetic acid