methyl 2-(benzylamino)acetate

Base Information

• Chemical Name: methyl 2-(benzylamino)acetate
• CAS No.: 17136-35-5
• Molecular Formula: C10H13 N O2 . Cl H
• Molecular Weight: 215.68
• Hs Code.: 2922499990
• Mol file: 17136-35-5.mol

Synonyms:Glycine,N-benzyl-, methyl ester, hydrochloride (8CI); N-Benzylglycine methyl esterhydrochloride

Chemical Property of methyl 2-(benzylamino)acetate

Chemical Property:

• Vapor Pressure: 0.0129mmHg at 25°C
• Boiling Point: 259.6°Cat760mmHg
• Flash Point: 110.8°C
• PSA: 38.33000
• Density: 1.069g/cm³
• LogP: 2.14210

Purity/Quality:

98%min ^*data from raw suppliers

Bzl-Gly-OMeHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-(benzylamino)acetate

There total 4 articles about methyl 2-(benzylamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + N-benzylglycine (17136-36-6) → N-benzyl glycine methyl ester hydrochloride (17136-35-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

ethyl 2-(benzylamino)acetate (6436-90-4) → N-benzyl glycine methyl ester hydrochloride (17136-35-5)

Guidance literature:

Multi-step reaction with 3 steps

2: aq. NaOH

3: SOCl₂

With sodium hydroxide; thionyl chloride;

DOI:10.1002/hlca.19680510108

Reference yield:

(ethoxycarbonylmethyl-benzyl-amino)-malonic acid diethyl ester (17136-38-8) → N-benzyl glycine methyl ester hydrochloride (17136-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH

2: SOCl₂

With sodium hydroxide; thionyl chloride;

DOI:10.1002/hlca.19680510108

upstream raw materials:

methanol

N-benzylglycine

ethyl 2-(benzylamino)acetate

(ethoxycarbonylmethyl-benzyl-amino)-malonic acid diethyl ester

Downstream raw materials:

3-Acetyl-4-benzyl-1-(4-chloro-phenyl)-4,5-dihydro-1H-[1,2,4]triazin-6-one

3-Acetyl-4-benzyl-1-(4-fluoro-phenyl)-4,5-dihydro-1H-[1,2,4]triazin-6-one

Boc-D-Pro-L-Pro-(Bzl)Gly-OMe

glycine ethyl ester hydrochloride