2-Hydroxy-5-{[hydroxy(5-methyl-3-phenyl-1,2-oxazol-4-yl)methylidene]amino}benzoic acid

Base Information

• Chemical Name: 2-Hydroxy-5-{[hydroxy(5-methyl-3-phenyl-1,2-oxazol-4-yl)methylidene]amino}benzoic acid
• CAS No.: 6157-41-1
• Molecular Formula: C18H14N2O5
• Molecular Weight: 344.374
• DSSTox Substance ID: DTXSID10977158
• Wikidata: Q82962240
• Mol file: 6157-41-1.mol

Synonyms:6157-41-1;CBMicro_002005;Oprea1_228341;Oprea1_488298;DTXSID10977158;SMSF0015460;CB03485;2-Hydroxy-5-{[hydroxy(5-methyl-3-phenyl-1,2-oxazol-4-yl)methylidene]amino}benzoic acid;BIM-0001945.P001

Chemical Property of 2-Hydroxy-5-{[hydroxy(5-methyl-3-phenyl-1,2-oxazol-4-yl)methylidene]amino}benzoic acid

Chemical Property:

• Vapor Pressure: 4.2E-12mmHg at 25°C
• Boiling Point: 531°C at 760 mmHg
• Flash Point: 274.9°C
• Density: 1.428g/cm³
• XLogP3: 3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 338.09027155
• Heavy Atom Count: 25
• Complexity: 494

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=NO1)C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O

Technology Process of 2-Hydroxy-5-{[hydroxy(5-methyl-3-phenyl-1,2-oxazol-4-yl)methylidene]amino}benzoic acid

There total 1 articles about 2-Hydroxy-5-{[hydroxy(5-methyl-3-phenyl-1,2-oxazol-4-yl)methylidene]amino}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenyl trimethylsiloxane (2996-92-1,46143-12-8) + benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → sodium bis(benzene-1,2-diolatophenyl)silicate (6157-41-1)

Guidance literature:

With sodium methylate; In methanol; at 45 ℃;

DOI:10.1246/bcsj.61.101

Reference yield: 85.0%

n-butyllithium (109-72-8,29786-93-4) + sodium bis(benzene-1,2-diolatophenyl)silicate (6157-41-1) → tributyl(phenyl)silane (18510-29-7)

Guidance literature:

In diethyl ether; for 1h; Heating;

Reference yield: 83.0%

sodium bis(benzene-1,2-diolatophenyl)silicate (6157-41-1) + cyclohexylmagnesium bromide (931-50-0) → dicyclohexylphenylsilane (18549-97-8)

Guidance literature:

In diethyl ether; at 20 ℃; for 15h;

DOI:10.1246/bcsj.61.101

upstream raw materials:

phenyl trimethylsiloxane

benzene-1,2-diol

Downstream raw materials:

tributyl(phenyl)silane

di-n-butylphenylsilane

dibutylphenyl(2-hydroxyphenoxy)silane

tert-butyl(phenyl)silane