Clofenamic acid

Base Information

Chemical Name:Clofenamic acid
CAS No.:4295-55-0
Molecular Formula:C13H9Cl2NO2
Molecular Weight:282.126
Hs Code.:2922499990
European Community (EC) Number:224-301-3
UNII:1X0MUE4C19
DSSTox Substance ID:DTXSID90195575
Nikkaji Number:J205.689E
Wikidata:Q27253005
NCI Thesaurus Code:C79707
ChEMBL ID:CHEMBL23115

Synonyms:Clofenamic acid;4295-55-0;2-(2,3-dichloroanilino)benzoic acid;Clofenaminsaeure;Clofenamic acid [INN];Acido clofenamico;Acide clofenamique;Acidum clofenamicum;2-[(2,3-dichlorophenyl)amino]benzoic acid;UNII-1X0MUE4C19;1X0MUE4C19;Acide clofenamique [INN-French];Acido clofenamico [INN-Spanish];Acidum clofenamicum [INN-Latin];EINECS 224-301-3;N-(2,3-Dichlorphenyl)anthranilsaeure;N-(2,3-Dichlorophenyl)anthranilic acid;Benzoic acid, 2-((2,3-dichlorophenyl)amino)-;Benzoic acid, 2-[(2,3-dichlorophenyl)amino]-;N-2,3-dichlorophenylanthranilic acid;CHEMBL23115;SCHEMBL1477650;CLOFENAMIC ACID [WHO-DD];DTXSID90195575;AKOS012847346;2-(2,3-dichlorophenylamino)benzoic acid;AC-11995;Anthranilic acid, N-(2,3-dichlorophenyl)-;FT-0762163;EN300-1267199;Q27253005;Z1136996802

Suppliers and Price of Clofenamic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
CLOFENAMIC ACID 95.00%
1MG
$ 727.65

AK Scientific
Clofenamicacid
500mg
$ 409.00

Total 23 raw suppliers

Chemical Property of Clofenamic acid

Chemical Property:

Appearance/Colour:yellowish crystalline powder
Vapor Pressure:2.33E-07mmHg at 25°C
Melting Point:256-257 °C
Refractive Index:1.677
Boiling Point:407.1 °C at 760 mmHg
PKA:3.61±0.36(Predicted)
Flash Point:200 °C
PSA：49.33000
Density:1.47 g/cm³
LogP:4.50820
XLogP3:6.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:281.0010339
Heavy Atom Count:18
Complexity:301

Purity/Quality:

99% ^*data from raw suppliers

CLOFENAMIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(=O)O)NC2=C(C(=CC=C2)Cl)Cl

Technology Process of Clofenamic acid

There total 6 articles about Clofenamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 4295-55-0
N-(2,3-dichloro-phenyl)-anthranilic acid

Guidance literature:: With copper; potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 12h;

Reference yield: 26.0%

: 608-27-5
2,3-dichloroaniline

: 88-65-3
2-bromobenzoic-acid

: 4295-55-0
N-(2,3-dichloro-phenyl)-anthranilic acid

Guidance literature:: With 4-methyl-morpholine; copper(I) oxide; In 1,4-dioxane; for 16h; Heating;
DOI:10.1021/jm00061a019

Reference yield: 24.0%

: 16497-87-3
potassium o-bromobenzoate

: 608-27-5
2,3-dichloroaniline

: 4295-55-0
N-(2,3-dichloro-phenyl)-anthranilic acid

Guidance literature:: With N-ethylmorpholine;; copper diacetate; In N,N-dimethyl-formamide; at 145 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.jinorgbio.2010.10.008