3-(Morpholin-4-ylmethyl)-5,5-diphenylimidazolidine-2,4-dione

Base Information

• Chemical Name: 3-(Morpholin-4-ylmethyl)-5,5-diphenylimidazolidine-2,4-dione
• CAS No.: 856-85-9
• Molecular Formula: C₂₀H₂₁N₃O₃
• Molecular Weight: 351.405
• DSSTox Substance ID: DTXSID201006182
• Wikidata: Q83001827
• ChEMBL ID: CHEMBL2237788
• Mol file: 856-85-9.mol

Synonyms:(3-(N-hydroxy)carboxamido-2-benzylpropanoyl)glycine;HCBP-Gly

Chemical Property of 3-(Morpholin-4-ylmethyl)-5,5-diphenylimidazolidine-2,4-dione

Chemical Property:

• PSA: 61.88000
• Density: 1.264g/cm³
• LogP: 1.97630
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 351.15829154
• Heavy Atom Count: 26
• Complexity: 502

Purity/Quality:

99%, ^*data from raw suppliers

3-(MORPHOLIN-4-YLMETHYL)-5,5-DIPHENYLIMIDAZOLIDINE-2,4-DIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CN2C(=O)C(NC2=O)(C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 3-(Morpholin-4-ylmethyl)-5,5-diphenylimidazolidine-2,4-dione

There total 3 articles about 3-(Morpholin-4-ylmethyl)-5,5-diphenylimidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

morpholine (110-91-8,99108-56-2) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + phenythoin (57-41-0) → 3-(morpholinomethyl)-5,5-diphenylimidazolidine-2,4-dione (856-85-9)

Guidance literature:

In N,N-dimethyl-formamide; Microwave irradiation;

DOI:10.1007/s00044-011-9611-7

Reference yield:

benzil (134-81-6) → 3-(morpholinomethyl)-5,5-diphenylimidazolidine-2,4-dione (856-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 0.58 h / Microwave irradiation; Alkaline conditions

2: N,N-dimethyl-formamide / Microwave irradiation

In dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Pinacol rearrangement;

DOI:10.1007/s00044-011-9611-7

Reference yield:

→ 3-(morpholinomethyl)-5,5-diphenylimidazolidine-2,4-dione (856-85-9)

Guidance literature:

5,5-Diphenyl-hydantoin, Morpholin, HCHO, EtOH;

DOI:10.1021/jm00325a025

upstream raw materials:

morpholine

formaldehyd

phenythoin

benzil

Downstream raw materials:

5-hydroxy-3,3-diphenyl-11-oxa-4,6,8-triazatricyclo<6.4.0.0^2,6>dodecan-5-one

1-methyl-5,5-diphenylimidazolidine-2,4-dione