(2,4-Dichlorophenyl)-dimethoxyphosphorylmethanol

Base Information

• Chemical Name: (2,4-Dichlorophenyl)-dimethoxyphosphorylmethanol
• CAS No.: 6329-49-3
• Molecular Formula: C₉H₁₁Cl₂O₄P
• Molecular Weight: 285.064
• NSC Number: 43448
• DSSTox Substance ID: DTXSID30286012
• Nikkaji Number: J2.971.124K

Synonyms:(2,4-dichlorophenyl)-dimethoxyphosphorylmethanol;6329-49-3;NSC43448;DTXSID30286012;NSC-43448;Dimethyl [(2,4-dichlorophenyl)(hydroxy)methyl]phosphonate

Chemical Property of (2,4-Dichlorophenyl)-dimethoxyphosphorylmethanol

Chemical Property:

• Vapor Pressure: 6.19E-07mmHg at 25°C
• Boiling Point: 394.6°C at 760 mmHg
• Flash Point: 192.4°C
• Density: 1.441g/cm³
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 283.9772012
• Heavy Atom Count: 16
• Complexity: 268

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COP(=O)(C(C1=C(C=C(C=C1)Cl)Cl)O)OC

Technology Process of (2,4-Dichlorophenyl)-dimethoxyphosphorylmethanol

There total 3 articles about (2,4-Dichlorophenyl)-dimethoxyphosphorylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

dimethyl trimethylsilyl phosphite (36198-87-5) + 2,4-dichlorobenzaldeyhde (874-42-0) → dimethyl 1-hydroxy-1-(2,4-dichlorophenyl)methylphosphonate (79296-55-2,6329-49-3)

Guidance literature:

dimethyl trimethylsilyl phosphite; 2,4-dichlorobenzaldeyhde; With 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene; In tetrahydrofuran; at 0 - 20 ℃; for 8h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; for 0.5h; Inert atmosphere;

DOI:10.1055/s-0030-1260045

Reference yield: 85.0%

2,4-dichlorobenzaldeyhde (874-42-0) + Dimethyl phosphite (868-85-9) → dimethyl 1-hydroxy-1-(2,4-dichlorophenyl)methylphosphonate (79296-55-2,6329-49-3)

Guidance literature:

With triethylamine; at 90 ℃; for 0.5h;

DOI:10.1016/S0040-4020(01)98937-9

Reference yield:

→ dimethyl 1-hydroxy-1-(2,4-dichlorophenyl)methylphosphonate (79296-55-2,6329-49-3)

Guidance literature:

2,4-Dichlor-benzaldehyd, Dimethylphosphit, wenig Triethylamin, (Erwaermen);

upstream raw materials:

2,4-dichlorobenzaldeyhde

Dimethyl phosphite

dimethyl trimethylsilyl phosphite

Downstream raw materials:

[(2,4-Dichloro-phenyl)-hydroxy-methyl]-phosphonic acid monomethyl ester

dimethyl [(2,4-dichlorophenyl)(6-oxo-6λ5-dibenzo[d,f][1,3,2]dioxaphosphepin-6-yl)ethyl]phosphonate

(2,4-dichlorophenyl)(dimethoxyphosphoryl)methyl cinnamate

O,O-dimethyl-2,6-pyridinyldi(formyloxy-2,4-dichlorobenzylphosphonate)

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