1,1-Dichloro-2-ethoxycyclopropane

Base Information

• Chemical Name: 1,1-Dichloro-2-ethoxycyclopropane
• CAS No.: 7363-99-7
• Molecular Formula: C5H8Cl2O
• Molecular Weight: 155.024
• NSC Number: 521348
• DSSTox Substance ID: DTXSID701300086
• Nikkaji Number: J2.389.949C
• Mol file: 7363-99-7.mol

Synonyms:1,1-Dichloro-2-ethoxycyclopropane;7363-99-7;Cyclopropane, 1,1-dichloro-2-ethoxy-;NSC 521348;BRN 2037103;ETHER, 2,2-DICHLOROCYCLOPROPYL ETHYL;4-06-00-00003 (Beilstein Handbook Reference);NSC521348;DTXSID701300086;2,2-dichlorocyclopropyl ethyl ether;AKOS025310554;NSC-521348;LS-67815

Chemical Property of 1,1-Dichloro-2-ethoxycyclopropane

Chemical Property:

• Vapor Pressure: 1.81mmHg at 25°C
• Boiling Point: 172.1°C at 760 mmHg
• Flash Point: 64.9°C
• PSA: 9.23000
• Density: 1.25g/cm³
• LogP: 1.96910
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 153.9952203
• Heavy Atom Count: 8
• Complexity: 92.4

Purity/Quality:

98%min ^*data from raw suppliers

1,1-Dichloro-2-ethoxycyclopropane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1CC1(Cl)Cl

Technology Process of 1,1-Dichloro-2-ethoxycyclopropane

There total 4 articles about 1,1-Dichloro-2-ethoxycyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

chloroform (67-66-3,8013-54-5) + ethyl vinyl ether (109-92-2,25104-37-4) → 1,1-dichloro-2-ethoxycyclopropane (7363-99-7)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; sodium hydroxide; In water; at 0 - 20 ℃; for 24h;

DOI:10.1021/op5001012

Reference yield: 84.0%

ethyl vinyl ether (109-92-2,25104-37-4) → 1,1-dichloro-2-ethoxycyclopropane (7363-99-7)

Guidance literature:

ethyl vinyl ether; With N-benzyl-N,N,N-triethylammonium chloride; In chloroform; for 0.166667h; Cooling with ice;

With sodium hydroxide; In chloroform; water; at 0 - 20 ℃; for 24h;

DOI:10.15227/orgsyn.083.0184

Reference yield:

chloral (75-87-6) + ethyl vinyl ether (109-92-2,25104-37-4) → 1,1-dichloro-2-ethoxycyclopropane (7363-99-7)

Guidance literature:

With potassium tert-butylate;

upstream raw materials:

chloroform

ethyl vinyl ether

chloral

Downstream raw materials:

2-chloroprop-2-enal diethyl acetal

1,1-diethoxy-but-2-ene

trans-ethoxy-1-chloro-2-cyclopropane

cis-ethoxy-1-chloro-2-cyclopropane

Refernces

• 1、 Kvernenes, Ole H.,Sydnes, Leiv K.,Arnold, David M.,Wipf, Peter. "Synthesis of 2-chloroacrolein diethyl acetal: (2-chloroprop-2-enal, diethyl acetal)". . p. 184 - 192. Retrieved 2017/09/13.