Guanosine, 8-(acetyl(4'-amino(1,1'-biphenyl)-4-yl)amino)-2'-deoxy-

Base Information

• Chemical Name: Guanosine, 8-(acetyl(4'-amino(1,1'-biphenyl)-4-yl)amino)-2'-deoxy-
• CAS No.: 82682-89-1
• Molecular Formula: C₂₄H₂₅N₇O₅
• Molecular Weight: 491.506
• Mol file: 82682-89-1.mol

Synonyms:

Chemical Property of Guanosine, 8-(acetyl(4'-amino(1,1'-biphenyl)-4-yl)amino)-2'-deoxy-

Chemical Property:

• PSA: 186.60000
• LogP: 2.19990

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Guanosine, 8-(acetyl(4'-amino(1,1'-biphenyl)-4-yl)amino)-2'-deoxy-

There total 4 articles about Guanosine, 8-(acetyl(4'-amino(1,1'-biphenyl)-4-yl)amino)-2'-deoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-acetoxy-N,N'-diacetylbenzidine (82682-97-1) → N-(deoxyguanosin-8-yl)-N-acetylbenzidine (82682-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 24 percent / sodium chloride; sodium citrate / acetonitrile; H₂O / 6 h / 37 °C / pH 7.0

2: pig esterase; rabbit esterase / aq. phosphate buffer; dimethylsulfoxide / 72 h / 37 °C / pH 7.7 / Enzymatic reaction

With pig esterase; rabbit esterase; sodium citrate; sodium chloride; In phosphate buffer; water; dimethyl sulfoxide; acetonitrile; 1: Substitution / 2: Deacetylation;

DOI:10.1021/tx00047a011

Reference yield:

N-(deoxyguanosin-8-yl)-N,N'-diacetylbenzidine (82682-90-4) → N-(deoxyguanosin-8-yl)-N-acetylbenzidine (82682-89-1)

Guidance literature:

With pig esterase; rabbit esterase; In phosphate buffer; dimethyl sulfoxide; at 37 ℃; for 72h; pH=7.7; Enzymatic reaction;

DOI:10.1021/tx00047a011

Reference yield:

4'-nitrobiphenyl-4-acetanilide (28533-02-0) → N-(deoxyguanosin-8-yl)-N-acetylbenzidine (82682-89-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 20 percent aq. ammonium sulfide / dimethylformamide / 18 h / 5 °C

2: ethyl acetate; pyridine / 18 h / 5 °C

3: 24 percent / sodium chloride; sodium citrate / acetonitrile; H₂O / 6 h / 37 °C / pH 7.0

4: pig esterase; rabbit esterase / aq. phosphate buffer; dimethylsulfoxide / 72 h / 37 °C / pH 7.7 / Enzymatic reaction

With ammonium sulfide; pig esterase; rabbit esterase; sodium citrate; sodium chloride; In pyridine; phosphate buffer; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 1: Reduction / 2: Acylation / 3: Substitution / 4: Deacetylation;

DOI:10.1021/tx00047a011

upstream raw materials:

N-(deoxyguanosin-8-yl)-N,N'-diacetylbenzidine

4'-nitrobiphenyl-4-acetanilide

N-(4'-hydroxyamino-biphenyl-4-yl)-acetamide

N-acetoxy-N,N'-diacetylbenzidine