4-nitro-4'-(acetylamino)biphenyl

Base Information

• Chemical Name: 4-nitro-4'-(acetylamino)biphenyl
• CAS No.: 28533-02-0
• Molecular Formula: C14H12 N2 O3
• Molecular Weight: 256.261
• Hs Code.: 2924299090
• Mol file: 28533-02-0.mol

Synonyms:Acetanilide,4'-(p-nitrophenyl)- (8CI); 4-Acetamido-4'-nitrobiphenyl;4-Acetoamino-4'-nitrobiphenyl

Chemical Property of 4-nitro-4'-(acetylamino)biphenyl

Chemical Property:

• PSA: 78.41000
• LogP: 4.39290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-nitro-4'-(acetylamino)biphenyl

There total 4 articles about 4-nitro-4'-(acetylamino)biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(4-acetylaminophenyl)boronic acid (101251-09-6) + 4-nitro-aniline (100-01-6,104810-17-5) → 4'-nitrobiphenyl-4-acetanilide (28533-02-0)

Guidance literature:

4-nitro-aniline; With tetrafluoroboric acid; sodium nitrite; In water; at 0 ℃; for 1h;

(4-acetylaminophenyl)boronic acid; With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); In water; acetonitrile; at 20 ℃; for 16h; Inert atmosphere; Schlenk technique; Irradiation;

DOI:10.1039/c6cc05078f

Reference yield: 91.0%

para-nitrophenyl bromide (586-78-7) + N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide (214360-60-8) → 4'-nitrobiphenyl-4-acetanilide (28533-02-0)

Guidance literature:

With sodium phosphate; palladium on activated charcoal; In water; isopropyl alcohol; at 20 ℃; for 10h;

DOI:10.1016/j.tet.2007.08.017

Reference yield:

4-amino-4'-nitrobiphenyl (1211-40-1) + acetic anhydride (108-24-7) → 4'-nitrobiphenyl-4-acetanilide (28533-02-0)

Guidance literature:

With acetic acid;

upstream raw materials:

4-amino-4'-nitrobiphenyl

acetic anhydride

para-nitrophenyl bromide

N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide

Downstream raw materials:

5-(4-Nitro-phenyl)-benzo[1,2,5]oxadiazole 1-oxide

N-(deoxyguanosin-8-yl)-N,N'-diacetylbenzidine

N-(deoxyguanosin-8-yl)-N-acetylbenzidine

N,N'-Diacetylbenzidin

Refernces

• 1、 Gauchot, Vincent,Lee, Ai-Lan. "Dual gold photoredox C(sp2)-C(sp2) cross couplings-development and mechanistic studies". supporting information. p. 10163 - 10166. Retrieved 2016/08/18.
• 2、 Monge, Antonio,Palop, Juan A.,Cerain, Adela Lopez de,Senador, Virginia,Martinez-Crespo, Francisko J.,et al.. "Hypoxia-Selective Agents Derived from Quinoxaline 1,4-Di-N-oxides". . p. 1786 - 1792. Retrieved 2007/10/02.