Ellipticine, 6-methyl

Base Information

• Chemical Name: Ellipticine, 6-methyl
• CAS No.: 18073-33-1
• Molecular Formula: C18H16N2
• Molecular Weight: 260.338
• NSC Number: 100596
• UNII: SX7G75DOG5
• DSSTox Substance ID: DTXSID20171004
• Nikkaji Number: J1.229.493J
• Wikidata: Q83041034
• ChEMBL ID: CHEMBL27112
• Mol file: 18073-33-1.mol

Synonyms:ELLIPTICINE, 6-METHYL;6-Methylellipticine;18073-33-1;6H-Pyrido[4,3-b]carbazole, 5,6,11-trimethyl-;SX7G75DOG5;NSC-100596;6H-Pyrido(4,3-b)carbazole, 5,6,11-trimethyl-;Ellipticine, 6-methyl-;NSC100596;NSC 100596;N-METHYLELLIPTICINE;UNII-SX7G75DOG5;N6-METHYLELLIPTICINE;CHEMBL27112;SCHEMBL1601900;DTXSID20171004;6H-Pyrido[4, 5,6,11-trimethyl-;5,6,11-TRIMETHYL-6H-PYRIDO(4,3-B)CARBAZOLE

Chemical Property of Ellipticine, 6-methyl

Chemical Property:

• Vapor Pressure: 2.48E-09mmHg at 25°C
• Boiling Point: 478.9°C at 760 mmHg
• Flash Point: 243.4°C
• Density: 1.17g/cm³
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 260.131348519
• Heavy Atom Count: 20
• Complexity: 368

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C=CN=CC2=C(C3=C1N(C4=CC=CC=C43)C)C

Technology Process of Ellipticine, 6-methyl

There total 39 articles about Ellipticine, 6-methyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.8%

ellipticine (519-23-3) + methyl iodide (74-88-4) → 6-methylellipticine (18073-33-1)

Guidance literature:

ellipticine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.3390/pathogens9070542

Reference yield: 86.0%

C28H33N3O6S (1618136-61-0) → 6-methylellipticine (18073-33-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 130 ℃; for 3h;

DOI:10.1016/j.ejmech.2014.05.032

Reference yield: 70.0%

C28H33N3O6S → 6-methylellipticine (18073-33-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; for 3h; Reflux;

upstream raw materials:

methyl magnesium iodide

5-carbethoxy,5,6-dimethyl-pyrido-<4,3-b>carbazol(5H)-11-one

ellipticine

methyl iodide

Downstream raw materials:

1-cyano-5,6,11-trimethylellipticine

1-cyano-2-p-tosyl-1,2-dihydro-5,6,11-trimethylellipticine

11-hydroxymethyl-5,6-dimethyl pyrido<4,3-b>carbazole

6-methyl-1,2-dihydroellipticin-1-one