N,N-dimethyl-3-phenylcyclohex-2-en-1-amine hydrochloride (1:1)

Base Information

• Chemical Name: N,N-dimethyl-3-phenylcyclohex-2-en-1-amine hydrochloride (1:1)
• CAS No.: 114506-97-7
• Molecular Formula: C₁₄H₁₉N*ClH
• Molecular Weight: 237.772
• Mol file: 114506-97-7.mol

Synonyms:2-Cyclohexen-1-amine,N,N-dimethyl-3-phenyl-, hydrochloride (9CI)

Chemical Property of N,N-dimethyl-3-phenylcyclohex-2-en-1-amine hydrochloride (1:1)

Chemical Property:

• Vapor Pressure: 0.00138mmHg at 25°C
• Boiling Point: 297.1°C at 760 mmHg
• Flash Point: 121.8°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-dimethyl-3-phenylcyclohex-2-en-1-amine hydrochloride (1:1)

There total 4 articles about N,N-dimethyl-3-phenylcyclohex-2-en-1-amine hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-phenylcyclohex-2-enone (10345-87-6) → N,N-dimethyl-3-phenyl-2-cyclohexen-1-amine hydrochloride (114506-97-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / sodium borohydride / methanol / 1.) 0 deg C, 30 min, 2.) room temperature, 1 h

2: 58 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 2.5 h / Ambient temperature

3: 1.) hydrazine hydrate, 2.) aq. HCl / 1.) methanol, reflux 2 h

4: 1.) sodium cyanoborohydride, 2.) HCl gas / 1.) acetonitrile, room temperature, 20 min, 2.) ether

With hydrogenchloride; sodium tetrahydroborate; sodium cyanoborohydride; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;

DOI:10.1021/jm00403a013

Reference yield:

3-phenyl-cyclohex-2-enol (17488-64-1) → N,N-dimethyl-3-phenyl-2-cyclohexen-1-amine hydrochloride (114506-97-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 58 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 2.5 h / Ambient temperature

2: 1.) hydrazine hydrate, 2.) aq. HCl / 1.) methanol, reflux 2 h

3: 1.) sodium cyanoborohydride, 2.) HCl gas / 1.) acetonitrile, room temperature, 20 min, 2.) ether

With hydrogenchloride; sodium cyanoborohydride; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1021/jm00403a013

Reference yield:

N-(3-phenyl-2-cyclohexenyl)phthalimide (114506-93-3) → N,N-dimethyl-3-phenyl-2-cyclohexen-1-amine hydrochloride (114506-97-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) hydrazine hydrate, 2.) aq. HCl / 1.) methanol, reflux 2 h

2: 1.) sodium cyanoborohydride, 2.) HCl gas / 1.) acetonitrile, room temperature, 20 min, 2.) ether

With hydrogenchloride; sodium cyanoborohydride; hydrazine hydrate;

DOI:10.1021/jm00403a013

upstream raw materials:

formaldehyd

3-phenyl-2-cyclohexen-1-amine hydrochloride

3-phenylcyclohex-2-enone

3-phenyl-cyclohex-2-enol

Refernces