2-[2-(2-Aminoethoxy)ethoxy]ethanol

Base Information

• Chemical Name: 2-[2-(2-Aminoethoxy)ethoxy]ethanol
• CAS No.: 6338-55-2
• Molecular Formula: C6H15NO3
• Molecular Weight: 149.19
• Hs Code.: 2922509090
• European Community (EC) Number: 804-174-6
• NSC Number: 40760
• DSSTox Substance ID: DTXSID00884261
• Nikkaji Number: J1.421.532H
• Wikidata: Q72436560
• ChEMBL ID: CHEMBL3092861
• Mol file: 6338-55-2.mol

Synonyms:6338-55-2;2-[2-(2-aminoethoxy)ethoxy]ethanol;2-(2-(2-Aminoethoxy)ethoxy)ethanol;Amino-PEG3-alcohol;NH2-PEG3;3,6,9-trioxadecylamine;Ethanol, 2-[2-(2-aminoethoxy)ethoxy]-;H2N-PEG3-OH;Triethylene glycol monoamine;(PEO)3-MONO-AMINE;Amino-PEG3;PROTAC Linker 35;MFCD07367495;2-[2-(2-hydroxyethoxy)ethoxy]ethylamine;CHEMBL3092861;AMINOETHOXY ETHOXY ETHANOL;2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol;Ethanol, 2-(2-(2-aminoethoxy)ethoxy)-;2-[2-(2-AMINOETHOXY)ETHOXY]ETHAN-1-OL;HO-PEG-NH2;NH2-PEG3-OH;triglycolamine;NSC40760;8-Amino-3,6-dioxaoctanol;SCHEMBL313703;8-Amino-3,6-dioxaoctane-1-ol;AMY4573;DTXSID00884261;BDBM50443640;NSC 40760;NSC-40760;AKOS006284316;AB31123;CS-W007545;HY-W007545;2-[2-(2-aminoethoxy)-ethoxy]-ethanol;2-(2-(2-Amino-ethoxy)-ethoxy)-ethanol;AS-20082;BP-20694;SY023358;A2420;FT-0775074;EN300-137387;H10924;2-[2-(2-Aminoethoxy)ethoxy]ethanol, >=96.0% (GC)

Chemical Property of 2-[2-(2-Aminoethoxy)ethoxy]ethanol

Chemical Property:

• Vapor Pressure: 0.00276mmHg at 25°C
• Refractive Index: 1.4645 (589.3 nm 20℃)
• Boiling Point: 253.8 °C at 760 mmHg
• PKA: 14.36±0.10(Predicted)
• Flash Point: 107.3 °C
• PSA: 64.71000
• Density: 1.054 g/cm³
• LogP: -0.32910
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 149.10519334
• Heavy Atom Count: 10
• Complexity: 61

Purity/Quality:

98%,99%, ^*data from raw suppliers

Amino-PEG3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi
• Hazard Codes: C,Xi
• Statements: 41-34-37/38
• Safety Statements: 26-39-45-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(COCCOCCO)N
• Description: (PEO)3-monoamine is a poly(ethylene oxide) (PEO) blocking reagent that prevents nonspecific adsorption of analytes in applications using covalent protein coupling such as ELISA. It reduces the adsorption of IgG when coated on carboxylic-terminated surfaces.

Technology Process of 2-[2-(2-Aminoethoxy)ethoxy]ethanol

There total 20 articles about 2-[2-(2-Aminoethoxy)ethoxy]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-[2-(2-azidoethoxy)ethoxy]ethanol (86520-52-7) → 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (6338-55-2)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1002/hlca.19910740810

Reference yield: 99.0%

8-dibenzylamino-3,6-dioxaoctan-1-ol (1349193-22-1) → 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (6338-55-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 70 ℃; under 52505.3 Torr; Continuous-flow conditions;

DOI:10.1016/j.tet.2011.09.124

Reference yield: 93.0%

2-(2′-(2″-bromoethoxy)ethoxy)ethanol (57641-67-5) → 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (6338-55-2)

Guidance literature:

With ammonium hydroxide; at 70 ℃; for 24h;

upstream raw materials:

N-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethyl}-acetamide

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

2-[2-(2-azidoethoxy)ethoxy]ethanol

2-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}isoindole-1,3-dione

Downstream raw materials:

3,6,12,15-tetraoxa-9-azaheptadecane-1,17-diol

tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)ethylcarbamate

5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pentanamide

5-(dimethylamino)-N-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}-1-naphthalenesulfonamide

Refernces

• 1、 Wang, Qiuhua,Zhong, Yulong,Miller, Daniel P.,Lu, Xiaoxing,Tang, Quan,Lu, Zhong-Lin,Zurek, Eva,Liu, Rui,Gong, Bing. "Self-Assembly and Molecular Recognition in Water: Tubular Stacking and Guest-Templated Discrete Assembly of Water-Soluble, Shape-Persistent Macrocycles". supporting information. p. 2915 - 2924. Retrieved 2020/02/04.
• 2、 Wang, Jue,Qi, Wenjing,Chen, Guosong. "The effect of monosaccharides on self-assembly of benzenetricarboxamides". supporting information. p. 587 - 591. Retrieved 2019/01/04.