5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pentanamide

Base Information

• Chemical Name: 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pentanamide
• CAS No.: 289714-02-9
• Molecular Formula: C₁₆H₂₉N₃O₅S
• Molecular Weight: 375.489
• Hs Code.: 2942000090
• Mol file: 289714-02-9.mol

Synonyms:5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pentanamide

Chemical Property of 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pentanamide

Chemical Property:

• Boiling Point: 704.2±60.0 °C(Predicted)
• Density: 1.198±0.06 g/cm3(Predicted)

Purity/Quality:

99%+, ^*data from raw suppliers

Biotin-PEG3-alcohol 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Biotin-PEG3-alcohol is a Biotin PEG linker containing a biotin group and a terminal primary hydroxyl (?OH) that reacts with a variety of functional groups.

Technology Process of 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pentanamide

There total 8 articles about 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (6338-55-2) + biotin pentafluorophenyl ester (120550-35-8) → 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pentanamide (289714-02-9,1263044-40-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 10h; Inert atmosphere;

DOI:10.1016/j.cclet.2016.11.016

Reference yield: 76.0%

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (6338-55-2) + biotin (58-85-5,22879-79-4) → 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pentanamide (289714-02-9,1263044-40-1)

Guidance literature:

biotin; With HATU; In N,N-dimethyl acetamide; at 0 ℃; for 0.166667h; Inert atmosphere;

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol; With triethylamine; In N,N-dimethyl acetamide; at 0 - 20 ℃; for 2h;

Reference yield:

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (6338-55-2) + D-(+)-biotin 2-nitrophenyl ester (33755-53-2) → 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pentanamide (289714-02-9,1263044-40-1)

Guidance literature:

DOI:10.1016/S0040-4039(00)00627-4

upstream raw materials:

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol

D-(+)-biotin 2-nitrophenyl ester

2-[2-(2-azidoethoxy)ethoxy]ethanol

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Refernces

• 1、 Zhou, Chunhua,Abdel-Rahman, Mona A.,Li, Wen,Liu, Kun,Zhang, Afang. "Thermoresponsive dendronized copolymers for protein recognitions based on biotin–avidin interaction". . p. 832 - 838. Retrieved 2017/05/16.