[2-Chloroethyl(2-fluoroethyl)amino]dichlorophosphine oxide

Base Information

• Chemical Name: [2-Chloroethyl(2-fluoroethyl)amino]dichlorophosphine oxide
• CAS No.: 5001-31-0
• Molecular Formula: C4H8Cl3FNOP
• Molecular Weight: 242.44
• Hs Code.: 2931900090
• Mol file: 5001-31-0.mol

Synonyms:WLN: OPGGN2G2F;

Chemical Property of [2-Chloroethyl(2-fluoroethyl)amino]dichlorophosphine oxide

Chemical Property:

• Vapor Pressure: 0.00434mmHg at 25°C
• Boiling Point: 278.1°C at 760 mmHg
• Flash Point: 122°C
• PSA: 30.12000
• Density: 1.464g/cm³
• LogP: 3.08240

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [2-Chloroethyl(2-fluoroethyl)amino]dichlorophosphine oxide

There total 2 articles about [2-Chloroethyl(2-fluoroethyl)amino]dichlorophosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

N-(2-chloroethyl)-N-(2-fluoroethyl)amine hydrochloride (871-74-9) → N-(2-chloroethyl)-N-(2-fluoroethyl)phosphoramidic dichloride (5001-31-0)

Guidance literature:

With trichlorophosphate;

DOI:10.1002/jlcr.954

Reference yield:

N-(2-chloroethyl)-N-(2-fluoroethyl)amine (44613-47-0) → N-(2-chloroethyl)-N-(2-fluoroethyl)phosphoramidic dichloride (5001-31-0)

Guidance literature:

With triethylamine; trichlorophosphate;

DOI:10.1021/jm00321a022

Reference yield:

N-(2-chloroethyl)-N-(2-fluoroethyl)phosphoramidic dichloride (5001-31-0) + propan-1-ol-3-amine (156-87-6) → 2-[(2-chloro-2'-fluorodiethyl)amino]-2H-1,3,2-oxazaphosphorinane-2-oxide (5001-29-6)

Guidance literature:

With triethylamine; In 1,4-dioxane;

DOI:10.1021/jm00321a022

upstream raw materials:

N-(2-chloroethyl)-N-(2-fluoroethyl)amine

N-(2-chloroethyl)-N-(2-fluoroethyl)amine hydrochloride

Downstream raw materials:

2-[(2-chloro-2'-fluorodiethyl)amino]-2H-1,3,2-oxazaphosphorinane-2-oxide

Refernces