4-hydrazinoquinazoline

Base Information

• Chemical Name: 4-hydrazinoquinazoline
• CAS No.: 36075-44-2
• Molecular Formula: C8H8 N4
• Molecular Weight: 160.178
• Hs Code.: 2933990090
• Mol file: 36075-44-2.mol

Synonyms:4(1H)-Quinazolinone,hydrazone (9CI); Quinazoline, 4-hydrazino- (6CI,7CI); 4-Hydrazinoquinazoline;KS 79

Chemical Property of 4-hydrazinoquinazoline

Chemical Property:

• Vapor Pressure: 1.97E-06mmHg at 25°C
• Melting Point: 186 °C (decomp)
• Boiling Point: 394.5°Cat760mmHg
• PKA: 2.79±0.20(Predicted)
• Flash Point: 192.4°C
• PSA: 63.83000
• Density: 1.373g/cm³
• LogP: 1.68870

Purity/Quality:

97% ^*data from raw suppliers

4-hydrazinoquinazoline ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-hydrazinoquinazoline

There total 13 articles about 4-hydrazinoquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-Hydroxyquinazoline (491-36-1) → quinazolin-4-ylhydrazine (36075-44-2)

Guidance literature:

With hydrazine hydrate; zinc(II) chloride; In 1,4-dioxane; at 150 ℃; for 8h;

DOI:10.14233/ajchem.2020.22837

Reference yield: 64.0%

4-chloroquinazoline (5190-68-1) → quinazolin-4-ylhydrazine (36075-44-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 4h; Reflux;

DOI:10.1016/j.ejmech.2012.06.003

Reference yield: 53.0%

4-Aminoquinazoline (15018-66-3) → quinazolin-4-ylhydrazine (36075-44-2)

Guidance literature:

With hydrazine hydrate; In ethanol; at 100 ℃; for 24h;

DOI:10.1016/j.jinorgbio.2020.111194

upstream raw materials:

4-chloroquinazoline

4-(methylsulfanyl)quinazoline

4-Aminoquinazoline

anthranilic acid nitrile

Downstream raw materials:

5-(2'-aminophenyl)-1,3,4-thiadiazole-2-thiol

4-(2-(2-chlorobenzylidene)hydrazinyl)quinazoline

N-(2,5-Dichloro-phenyl)-N-[4-(quinazolin-4-yl-hydrazonomethyl)-thiazol-2-yl]-acetamide

N-[1-(2,4-Dichloro-phenyl)-meth-(E)-ylidene]-N'-quinazolin-4-yl-hydrazine