15018-66-3

Basic information

• Product Name: QUINAZOLIN-4-YLAMINE
• Synonyms: QUINAZOLIN-4-YLAMINE;4-QUINAZOLINAMINE;4-QUINAZOLINEAMINE;4-QUINAZOLINYLAMINE;4-Quinazolinamine (9CI);4-AMINOQUINAZOLINE ;quinazolin-4-amine;Quinazoline-4-amine
• CAS NO: 15018-66-3
• Molecular Formula: C₈H₇N₃
• Molecular Weight: 145.16
• Product Categories: PYRIMIDINE
• Mol File: 15018-66-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 274-275℃
• Boiling Point: 328.3 °C at 760 mmHg
• Flash Point: 178.6 °C
• Appearance: /Solid
• Density: 1.292 g/cm³
• Vapor Pressure: 0.000191mmHg at 25°C
• Refractive Index: 1.723
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 5.86±0.30(Predicted)
• CAS DataBase Reference: QUINAZOLIN-4-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: QUINAZOLIN-4-YLAMINE(15018-66-3)
• EPA Substance Registry System: QUINAZOLIN-4-YLAMINE(15018-66-3)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• RIDADR: 2811
• RTECS: VA1236000
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 15018-66-3(Hazardous Substances Data)

Usage

General Description

Quinazolin-4-ylamine is a chemical compound with the molecular formula C8H7N3. It is a heterocyclic amine with a quinazoline ring structure, and is commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. Quinazolin-4-ylamine is known for its use in the development of various bioactive molecules, including antiviral and anticancer agents. It has also been studied for its potential role in treating conditions such as diabetes and hypertension. QUINAZOLIN-4-YLAMINE has been the subject of research and development due to its diverse pharmacological properties and potential therapeutic applications.

InChI:InChI=1/C8H7N3/c9-8-6-3-1-2-4-7(6)10-5-11-8/h1-5H,(H2,9,10,11)

Upstream product

• 5190-68-1 4-chloroquinazoline 
• 3473-63-0 formamidine acetic acid 
• 1885-29-6 anthranilic acid nitrile 
• 122-51-0 orthoformic acid triethyl ester 
• 253-82-7 quinazoline 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 77287-34-4 formamide 
• 1227920-69-5 (E)-N’-(2-cyanophenyl)-N,N-dimethylformimidamide 
• 463-52-5 formamidine 
• 491-36-1 4-Hydroxyquinazoline 
• 74-90-8 hydrogen cyanide 
• 234-72-0 imidazo[1,2-c]quinazoline 
• 125735-12-8 dimethyl N^α-(4-quinazolyl)aspartate 
• 16347-97-0 4-phenoxy-quinazoline 

Downstream Products

• 106949-83-1 4-nitro-benzenesulfonic acid quinazolin-4-ylamide 
• 128036-79-3 N-(4-quinazolinyl)-4'-methoxybenzimidoyl cyanide 
• 128036-81-7 3-bromo-2-(4'-methoxyphenyl)imidazo<1,2-c>quinazoline 
• 128036-78-2 3-nitroso-2-(4'-methoxyphenyl)imidazo<1,2-c>quinazoline 
• 128036-80-6 2-(3',5'-dinitro-4'-methoxyphenyl)imidazo<1,2-c>quinazoline 
• 2442-46-8 sulfanilic acid quinazolin-4-ylamide 
• 457072-64-9 N₁,N₁-dimethyl-N₂-(quinazolin-4-yl)-3-methylbenzamidine 
• 457072-63-8 N₁,N₁-dimethyl-N₂-(quinazolin-4-yl)-4-fluorobenzamidine 
• 457072-62-7 N₁,N₁-dimethyl-N₂-(quinazolin-4-yl)-4-chlorobenzamidine 
• 457072-61-6 N₁,N₁-dimethyl-N₂-(quinazolin-4-yl)benzamidine 
• 1418025-63-4 7-chloro-4-oxo-1-phenyl-3-(quinazolin-4-ylaminomethyl)-1,4-dihydro-quinoline-2-carboxylic acid methyl ester 
• 100818-54-0 benzyl-quinazolin-4-yl-amine 
• 95862-54-7 1-Phenyl-2-(quinazolin-4-ylamino)-ethanone; hydrobromide 
• 868365-72-4 1-(2-p-tolyl-2H-[1,2,4]triazolo[1,5-c]quinazolin-3-yl)-ethanone 

Relevant articles and documents

Synthesis of new tetracyclic azaheteroaromatic cores via auto-tandem Pd-catalyzed and one-pot Pd- and Cu-catalyzed double C-N bond formation

Inter- and intramolecular transition metal-catalyzed amination of 2-chloro-3-iodopyridine and 2,3-dibromopyridine, respectively, with benzodiazinamines yielded six hitherto unknown tetracyclic azaheteroaromatic cores. C-N bond formation was achieved via auto-tandem (Pd-catalyst) as well as one-pot (sequential use of a Pd- and Cu-catalyst) catalysis.

One-pot three-component synthesis of 2-substituted 4-aminoquinazolines

A facile and rapid synthesis of the title compounds via one-pot reaction of 2-aminobenzonitrile, orthoesters and ammonium acetate under solvent-free and microwave condition is described.

Novel compound or pharmaceutically acceptable salt thereof and pharmaceutical composition for prevention or treatment of disease caused by influenza virus infection containing the same as an active ingredient

The present invention relates to a novel compound or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active component for preventing or treating diseases related with influenza virus infection. The novel compound represented by chemical formula 1 has remarkable antivirus activity against influenza virus without cytotoxicity to human cells and thus has little side effects to human bodies. Therefore, the pharmaceutical composition having the same as an active component can be usefully used for preventing or treating diseases which occur through influenza virus infection such as flu, cold, sore throat, bronchitis, pneumonia, avian influenza, swine flu, goat flu, etc.COPYRIGHT KIPO 2016

Synthesis of a new isomer of creatinine and its use in the preparation of the food mutagen 2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (PHIP)

Base-induced cyclization of N′-cyanomethyl-N′-methylurea gives 1-methyl-4-amino-imidazol-2-one, this in turn is condensed with 3-hydroxy-2-phenylacrolein to yield an imidazo[4,5-b]pyridine which is converted into 2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (PHIP).