(4-Aminophenyl)piperidin-1-ylmethanone

Base Information

• Chemical Name: (4-Aminophenyl)piperidin-1-ylmethanone
• CAS No.: 42837-37-6
• Molecular Formula: C12H16N2O
• Molecular Weight: 204.272
• Hs Code.: 29339900
• Mol file: 42837-37-6.mol

Synonyms:Piperidine,1-(4-aminobenzoyl)- (9CI);Piperidine, 1-(p-aminobenzoyl)- (7CI);(4-Aminobenzoyl)-1-piperidide;1-(4-Aminobenzoyl)piperidine;1-(p-Aminobenzoyl)piperidine;4-(1-Piperidinylcarbonyl)aniline;N-(p-Aminobenzoyl)piperidine;

Chemical Property of (4-Aminophenyl)piperidin-1-ylmethanone

Chemical Property:

• Vapor Pressure: 9.34E-06mmHg at 25°C
• Melting Point: 161-162 °C
• Boiling Point: 402.4 °C at 760 mmHg
• PKA: 3.56±0.10(Predicted)
• Flash Point: 197.2 °C
• PSA: 46.33000
• Density: 1.155 g/cm³
• LogP: 2.41400
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-(1-Piperidinylcarbonyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-Aminophenyl)piperidin-1-ylmethanone

There total 8 articles about (4-Aminophenyl)piperidin-1-ylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(p-nitrobenzoyl)azacyclohexane (20857-92-5) → 4-(N-piperidinocarbonyl)aniline (42837-37-6)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; for 16h;

Reference yield: 88.0%

N-(4-chlorobenzoyl)piperidine (26163-40-6) → 4-(N-piperidinocarbonyl)aniline (42837-37-6)

Guidance literature:

With dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C₅₀H₇₀NO₄PPdS; C₅₀H₇₀NO₄PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate; In 1,4-dioxane; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol401612c

Reference yield: 54.0%

N-Formylpiperidine (2591-86-8) + 4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 4-(N-piperidinocarbonyl)aniline (42837-37-6)

Guidance literature:

With tert.-butylhydroperoxide; [Cu(1,3-bis(carboxymethyl)imidazole)₂]; In water; at 100 ℃; for 1.66667h; Kinetics;

DOI:10.1002/ejoc.201600991

upstream raw materials:

N-(p-nitrobenzoyl)azacyclohexane

piperidine

4-nitro-benzoyl chloride

N-(4-chlorobenzoyl)piperidine

Downstream raw materials:

1-{4-[(2-oxo-benzooxazol-3-ylmethyl)-amino]-benzoyl}-piperidine

1-{4-[(2-thioxo-benzooxazol-3-ylmethyl)-amino]-benzoyl}-piperidine

1-{4-[(2-thioxo-benzothiazol-3-ylmethyl)-amino]-benzoyl}-piperidine

5-Benzylidene-3--4-oxo-thiazolidine-2-thione