26163-40-6

Basic information

• Product Name: (4-Chlorophenyl)(piperidin-1-yl)methanone
• Synonyms: (4-Chlorophenyl)(piperidin-1-yl)methanone
• CAS NO: 26163-40-6
• Molecular Formula: C₁₂H₁₄ClNO
• Molecular Weight: 223.7
• Product Categories: blocks;Carboxes
• Mol File: 26163-40-6.mol
• Article Data: 63

Chemical Properties

• Melting Point: 74 °C
• Boiling Point: 362.6°C at 760 mmHg
• Flash Point: 173.1°C
• Appearance: /
• Density: 1.199g/cm³
• Vapor Pressure: 1.91E-05mmHg at 25°C
• Refractive Index: 1.569
• PKA: -1.42±0.20(Predicted)
• CAS DataBase Reference: (4-Chlorophenyl)(piperidin-1-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Chlorophenyl)(piperidin-1-yl)methanone(26163-40-6)
• EPA Substance Registry System: (4-Chlorophenyl)(piperidin-1-yl)methanone(26163-40-6)

Safety Data

• Hazardous Substances Data: 26163-40-6(Hazardous Substances Data)

Usage

General Description

(4-Chlorophenyl)(piperidin-1-yl)methanone is a chemical compound with the molecular formula C13H16ClNO. It is a synthetic substance that belongs to the class of arylcyclohexylamines, which are psychoactive drugs with dissociative and hallucinogenic effects. This particular compound is a derivative of the designer drug ketamine and has similar effects on the central nervous system. It is known to cause altered perceptions, hallucinations, and dissociation from the physical body. Additionally, it may also have sedative and analgesic properties. Due to its potential for abuse and adverse health effects, it is classified as a controlled substance in many jurisdictions.

InChI:InChI=1/C12H14ClNO/c13-11-6-4-10(5-7-11)12(15)14-8-2-1-3-9-14/h4-7H,1-3,8-9H2

Upstream product

• 110-89-4 piperidine 
• 74-11-3 para-chlorobenzoic acid 
• 3335-29-3 (4-chlorophenyl)(piperidin-1-yl)methanethione 
• 6264-29-5 4-nitrophenyl 4-chlorobenzoate 
• 104-88-1 4-chlorobenzaldehyde 
• 100-02-7 4-nitro-phenol 
• 122-01-0 4-chloro-benzoyl chloride 
• 2156-71-0 N-chloropiperidine 
• 73686-49-4 4-Chloro-benzoic acid pyridin-2-yl ester 
• 873-76-7 para-Chlorobenzyl alcohol 
• 106-43-4 para-chlorotoluene 
• 637-87-6 1-Chloro-4-iodobenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 5542-49-4 piperidin-1-yl benzoate 

Downstream Products

• 143901-82-0 C₂₄H₂₈Cl₂N₂ 
• 143901-81-9 C₂₄H₂₈Cl₂N₂ 
• 3335-29-3 (4-chlorophenyl)(piperidin-1-yl)methanethione 
• 76335-56-3 1-[(2,3-Dihydro-4H-1,4-benzodioxin)-2-ylmethyl]-4-(4-chloro-benzoyl)piperidine 
• 137374-28-8 N-benzyl-4-chloro-N-methylbenzamide 
• 411209-38-6 (piperidin-1-yl)-(4-(trifluoromethyl)phenyl)methanone 
• 42837-37-6 4-(N-piperidinocarbonyl)aniline 
• 59507-42-5 1-(4-chlorobenzyl)piperidine 
• 59746-58-6 (4-ethylphenyl)(piperidin-1-yl)methanone 

Relevant articles and documents

Amide Bond Formation via Aerobic Photooxidative Coupling of Aldehydes with Amines Catalyzed by a Riboflavin Derivative

We report an effective, operationally simple, and environmentally friendly system for the synthesis of tertiary amides by the oxidative coupling of aromatic or aliphatic aldehydes with amines mediated by riboflavin tetraacetate (RFTA), an inexpensive organic photocatalyst, and visible light using oxygen as the sole oxidant. The method is based on the oxidative power of an excited flavin catalyst and the relatively low oxidation potential of the hemiaminal formed by amine to aldehyde addition.

Solar and visible-light active nano Ni/g-C3N4photocatalyst for carbon monoxide (CO) and ligand-free carbonylation reactions

In this study, we investigate the amino and alkoxycarbonylation reaction between various substituted aryl halides, benzyl iodides, and iodocyclohexane with different types of amines and alcohols in the absence of carbon monoxide gas and ligands. Similar reactions are carried out at high temperatures, in the presence of appropriate ligands, stoichiometric amounts of bases, and gaseous carbon monoxide, which endanger the health of organic chemists. We present a novel method that does not utilize ligands, bases, gaseous CO, and special conditions. This procedure is a redox reaction carried out by new economic nano Ni/g-C3N4at room temperature and under visible light. Mo(CO)6was used toin situgenerate CO, to resolve the problems caused by the use of CO gas. This protocol has the ability to be used on a gram scale by using a continuous flow reactor.

Organophotoredox-Mediated Amide Synthesis by Coupling Alcohol and Amine through Aerobic Oxidation of Alcohol

The combination of an organic photocatalyst [4CzIPN (1,2,3,5-tetrakis(carbazol-9-yl)-4,6 dicyanobenzene) or 5MeOCzBN (2,3,4,5,6-pentakis(3,6-dimethoxy-9 H-carbazol-9-yl)benzonitrile)], quinuclidine, and tetra-n-butylammonium phosphate (hydrogen-bonding catalyst) was employed for amide bond formations. The hydrogen-bonded OH group activated the adjacent C?H bond of alcohols towards hydrogen atom transfer (HAT) by a radical species. The quinuclidinium radical cation, generated through single-electron oxidation of quinuclidine by the photocatalyst, employed to abstract a hydrogen atom from the α-C?H bond of alcohols selectively due to a polarity effect-produced α-hydroxyalkyl radical, which subsequently converted to the corresponding aldehyde under aerobic conditions. Then the coupling of the aldehyde and an amine formed a hemiaminal intermediate that upon photocatalytic oxidation produced the amide.