Furan-2-ylmethyl-(4-methoxy-benzyl)-amine

Base Information

• Chemical Name: Furan-2-ylmethyl-(4-methoxy-benzyl)-amine
• CAS No.: 225236-03-3
• Molecular Formula: C13H15NO2
• Molecular Weight: 217.268
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID00355123
• Nikkaji Number: J1.085.261G
• Wikidata: Q82133787
• Mol file: 225236-03-3.mol

Synonyms:Furan-2-ylmethyl-(4-methoxy-benzyl)-amine;225236-03-3;N-(furan-2-ylmethyl)-1-(4-methoxyphenyl)methanamine;furan-2-ylmethyl-(4-methoxybenzyl)amine;1-(furan-2-yl)-N-(4-methoxybenzyl)methanamine;TimTec1_007155;Oprea1_818171;Oprea1_842115;SCHEMBL17080774;DTXSID00355123;HMS1554F05;BBL010627;STK128599;AKOS000130456;CS-0318288;FT-0644058

Chemical Property of Furan-2-ylmethyl-(4-methoxy-benzyl)-amine

Chemical Property:

• Vapor Pressure: 0.000312mmHg at 25°C
• Refractive Index: 1.545
• Boiling Point: 320.7 °C at 760 mmHg
• Flash Point: 147.8 °C
• PSA: 34.40000
• Density: 1.094 g/cm³
• LogP: 2.96890
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 217.110278721
• Heavy Atom Count: 16
• Complexity: 190

Purity/Quality:

98%min ^*data from raw suppliers

1-(Furan-2-yl)-N-(4-methoxybenzyl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CNCC2=CC=CO2

Technology Process of Furan-2-ylmethyl-(4-methoxy-benzyl)-amine

There total 13 articles about Furan-2-ylmethyl-(4-methoxy-benzyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(furan-2-ylmethylene)-1-(4-methoxyphenyl)methanamine → 1-(furan-2-yl)-N-(4-methoxybenzyl)methanamine (225236-03-3)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃;

DOI:10.1016/j.poly.2014.03.041

Reference yield: 89.0%

furfural (98-01-1) + 4-methoxy-benzylamine (2393-23-9) → 1-(furan-2-yl)-N-(4-methoxybenzyl)methanamine (225236-03-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 50 ℃; under 37503.8 Torr;

DOI:10.1039/c3ra47657j

Reference yield: 80.0%

furan-2-ylmethanamine (617-89-0) + 4-methoxybenzonitrile (874-90-8) → 1-(furan-2-yl)-N-(4-methoxybenzyl)methanamine (225236-03-3)

Guidance literature:

With hydrogen; In para-xylene; at 90 ℃; for 20h; under 750.075 Torr; chemoselective reaction;

DOI:10.1021/acscatal.0c04379

upstream raw materials:

N-(4-methoxybenzylidene)(furan-2-yl)methanamine

furan-2-ylmethanamine

4-methoxy-benzaldehyde

furfural

Downstream raw materials:

(Z)-N-furfuryl-N-(4-methoxybenzyl)-3-iodocrylamide

(E)-N-furfuryl-N-(4-methoxybenzyl)-3-iodocrylamide

Refernces

• 1、 Hizartzidis, Lacey,Gilbert, Jayne,Gordon, Christopher P.,Sakoff, Jennette A.,McCluskey, Adam. "Synthesis and Cytotoxicity of Octahydroepoxyisoindole-7-carboxylic Acids and Norcantharidin–Amide Hybrids as Norcantharidin Analogues". supporting information. p. 1152 - 1161. Retrieved 2019/05/24.
• 2、 Sathiyaraj,Thirumaran,Ciattini, Samuele. "Synthesis and spectral studies on Ni(II) complexes involving N-furfuryl-N-substituted benzyldithiocarbamates and PPh3: Anagostic and C–H…π(chelate) interactions in (N-furfuryl-N-(4-fluorobenzyl)dithiocarbamato-S,S′)(thiocyanato-N)(tr". . p. 1042 - 1050. Retrieved 2016/07/06.