ethyl 6-Methoxy-2-naphthoate

Base Information

• Chemical Name: ethyl 6-Methoxy-2-naphthoate
• CAS No.: 6297-10-5
• Molecular Formula: C₁₄H₁₄O₃
• Molecular Weight: 230.263
• Mol file: 6297-10-5.mol

Synonyms:6-Methoxy-naphthoesaeure-(2)-ethylester;6-Methoxy-naphthalin-2-carbonsaeure-aethylester;ethyl 6-methoxy-2-naphthoate;6-methoxy-[2]naphthoic acid ethyl ester;6-Methoxy-[2]naphthoesaeure-aethylester;

Chemical Property of ethyl 6-Methoxy-2-naphthoate

Chemical Property:

• Vapor Pressure: 2.74E-05mmHg at 25°C
• Boiling Point: 357.4°C at 760 mmHg
• Flash Point: 149°C
• PSA: 35.53000
• Density: 1.14g/cm³
• LogP: 3.02510

Purity/Quality:

99%min ^*data from raw suppliers

6-Methoxy-naphthalene-2-carboxylicacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 6-Methoxy-2-naphthoate

There total 7 articles about ethyl 6-Methoxy-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethanol (64-17-5) + 2-Bromo-6-methoxynaphthalene (5111-65-9) + molybdenum hexacarbonyl (13939-06-5,199620-15-0) → ethyl 6-methoxy-2-naphthoate (6297-10-5)

Guidance literature:

With oxygen; palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; at 120 ℃; for 0.5h; Microwave irradiation;

DOI:10.1021/jm201212h

Reference yield: 91.0%

ethanol (64-17-5) + 2-methoxy-6-naphthoic acid (2471-70-7) → ethyl 6-methoxy-2-naphthoate (6297-10-5)

Guidance literature:

With hydrogenchloride; for 6h; Heating;

DOI:10.1248/cpb.31.2006

Reference yield: 85.0%

1-(6-methoxy-2-naphthyl)-4,4,4-trifluorobutane-1,3-dione + ethanol (64-17-5) → ethyl 6-methoxy-2-naphthoate (6297-10-5)

Guidance literature:

1-(6-methoxy-2-naphthyl)-4,4,4-trifluorobutane-1,3-dione; ethanol; With pyridine; iodine; copper(II) oxide; for 24h; Reflux;

With potassium carbonate; for 10h; Reflux;

DOI:10.1246/bcsj.81.369

upstream raw materials:

2-methoxy-6-naphthoic acid

ethanol

6-methoxy-2-naphthoyl chloride

6-methoxy-3,4-dihydronaphthalene-2-carboxylic acid

Downstream raw materials:

2-(chloromethyl)-6-methoxynaphthalene

1-benzhydryl-4-(6-methoxy-2-naphthyl)methylpiperazine hydrochloride

1-benzhydryl-4-(6-methoxy-2-naphthyl)methylpiperazine

Refernces

• 1、 Gising, Johan,Nilsson, Mikael T.,Odell, Luke R.,Yahiaoui, Samir,Lindh, Martin,Iyer, Harini,Sinha, Achyut M.,Srinivasa, Bachally R.,Larhed, Mats,Mowbray, Sherry L.,Karlén, Anders. "Trisubstituted imidazoles as mycobacterium tuberculosis glutamine synthetase inhibitors". supporting information; experimental part. p. 2894 - 2898. Retrieved 2012/06/01.
• 2、 Liu, Kwang-Ting,Hwang, Patty Y.-H.,Chen, Hun-I.. "Solvolyses of naphthoyl chlorides. Solvent effect and Grunwald-Winstein correlation analyses with YxBnCl scales". . p. 750 - 757. Retrieved 2007/10/03.