4-((2,4-Diamino-5-pyrimidinyl)methyl)-2,6-dimethoxy-alpha-ethylbenzenemethanol

Base Information

Chemical Name:4-((2,4-Diamino-5-pyrimidinyl)methyl)-2,6-dimethoxy-alpha-ethylbenzenemethanol
CAS No.:55687-83-7
Molecular Formula:C16H22N4O3
Molecular Weight:318.3709
Hs Code.:
DSSTox Substance ID:DTXSID60971045

Synonyms:BRN 5992024;4-((2,4-Diamino-5-pyrimidinyl)methyl)-2,6-dimethoxy-alpha-ethylbenzenemethanol;Benzenemethanol, 4-((2,4-diamino-5-pyrimidinyl)methyl)-2,6-dimethoxy-alpha-ethyl-;55687-83-7;SCHEMBL11860332;DTXSID60971045;LS-30680;1-{4-[(2,4-Diimino-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-2,6-dimethoxyphenyl}propan-1-ol

Suppliers and Price of 4-((2,4-Diamino-5-pyrimidinyl)methyl)-2,6-dimethoxy-alpha-ethylbenzenemethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-((2,4-Diamino-5-pyrimidinyl)methyl)-2,6-dimethoxy-alpha-ethylbenzenemethanol

Chemical Property:

Vapor Pressure:3.85E-16mmHg at 25°C
Boiling Point:618.2°C at 760 mmHg
Flash Point:327.7°C
Density:1.246g/cm³
XLogP3:1.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:318.16919058
Heavy Atom Count:23
Complexity:346

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(C1=C(C=C(C=C1OC)CC2=CN=C(N=C2N)N)OC)O

Technology Process of 4-((2,4-Diamino-5-pyrimidinyl)methyl)-2,6-dimethoxy-alpha-ethylbenzenemethanol

There total 7 articles about 4-((2,4-Diamino-5-pyrimidinyl)methyl)-2,6-dimethoxy-alpha-ethylbenzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 50-01-1
guanidine hydrochloride

: (Z)-2-[4-(1-Hydroxy-propyl)-3,5-dimethoxy-benzyl]-3-phenylamino-acrylonitrile

: 55687-83-7
4-[(2,4-diamino-5-pyrimidinyl)-methyl]-α-ethyl-2,6-dimethoxy-benzyl alcohol

Guidance literature:: With sodium methylate; In ethanol; for 40h; Heating;

Reference yield:

: 33187-98-3
3,5-dimethoxy-4-(methoxycarbonyl)benzaldehyde

: 55687-83-7
4-[(2,4-diamino-5-pyrimidinyl)-methyl]-α-ethyl-2,6-dimethoxy-benzyl alcohol

Guidance literature:: Multi-step reaction with 6 steps

1: conc. HCl / ethanol / 2 h / Heating

2: 12 percent / diethyl ether / 3 h / Heating

3: aq. HCl

4: sodium methylate / dimethylformamide / 0.25 h / 75 °C

5: propan-2-ol / 0.5 h / Heating

6: 55 percent / sodium methylate / ethanol / 40 h / Heating

With hydrogenchloride; sodium methylate; In hydrogenchloride; diethyl ether; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 16849-68-6
dimethyl 2,6-dimethoxyterephthalate

: 55687-83-7
4-[(2,4-diamino-5-pyrimidinyl)-methyl]-α-ethyl-2,6-dimethoxy-benzyl alcohol

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / sodium bis(2-methoxyethoxy)aluminum hyride, morpholine / toluene / 4 h / -15 °C

2: conc. HCl / ethanol / 2 h / Heating

3: 12 percent / diethyl ether / 3 h / Heating

4: aq. HCl

5: sodium methylate / dimethylformamide / 0.25 h / 75 °C

6: propan-2-ol / 0.5 h / Heating

7: 55 percent / sodium methylate / ethanol / 40 h / Heating

With morpholine; hydrogenchloride; sodium methylate; sodium bis(2-methoxyethoxy)aluminium dihydride; In hydrogenchloride; diethyl ether; ethanol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;