ETHYL 2-(2-BENZOYL-4-CHLOROANILINO)-2-OXOACETATE

Base Information

• Chemical Name: ETHYL 2-(2-BENZOYL-4-CHLOROANILINO)-2-OXOACETATE
• CAS No.: 19144-20-8
• Molecular Formula: C17H14 Cl N O4
• Molecular Weight: 331.755
• Hs Code.: 2924299090
• Mol file: 19144-20-8.mol

Synonyms:Aceticacid, [(2-benzoyl-4-chlorophenyl)amino]oxo-, ethyl ester (9CI); Oxanilic acid,2'-benzoyl-4'-chloro-, ethyl ester (8CI)

Chemical Property of ETHYL 2-(2-BENZOYL-4-CHLOROANILINO)-2-OXOACETATE

Chemical Property:

• Vapor Pressure: 0.0136mmHg at 25°C
• Melting Point: 139-141°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 72.47000
• Density: 1.331g/cm³
• LogP: 3.14560

Purity/Quality:

99% ^*data from raw suppliers

Ethyl [(2-benzoyl-4-chlorophenyl)-amino](oxo)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-(2-BENZOYL-4-CHLOROANILINO)-2-OXOACETATE

There total 2 articles about ETHYL 2-(2-BENZOYL-4-CHLOROANILINO)-2-OXOACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-chloro-2-aminobenzophenone (719-59-5) + Ethyl oxalyl chloride (4755-77-5) → N-(2-benzoyl-4-chlorophenyl)oxalamic acid ethyl ester (19144-20-8)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 2.25h; Inert atmosphere;

DOI:10.15227/orgsyn.076.0142

Reference yield:

→ N-(2-benzoyl-4-chlorophenyl)oxalamic acid ethyl ester (19144-20-8)

Guidance literature:

2-Amino-5-chlor-benzophenon, ClCO-COO-C2H5;

Reference yield: 93.0%

N-(2-benzoyl-4-chlorophenyl)oxalamic acid ethyl ester (19144-20-8) → ethyl 3-phenyl-5-chloroindole-2-carboxylate (21139-32-2)

Guidance literature:

With titanium; pyrographite; In 1,2-dimethoxyethane; for 1h; Heating;

DOI:10.1039/C39930000211

upstream raw materials:

5-chloro-2-aminobenzophenone

Ethyl oxalyl chloride

Downstream raw materials:

ethyl 3-phenyl-5-chloroindole-2-carboxylate

2-N-Methyl-ethyloxalylamino-5-chlor-benzophenon

Refernces

• 1、 Fürstner, Alois,Hupperts, Achim,Seidel, Günter,Hillier, Michael C.,Martin, Stephen F.. "Ethyl 5-chloro-3-phenylindole-2-carboxylate [ 1H-Indole-2-carboxylic acid, 5-chloro-3-phenyl-, ethyl ester ]". . p. 142 - 142. Retrieved 2017/09/25.